Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Italy.
Vet J. 2010 Dec;186(3):364-9. doi: 10.1016/j.tvjl.2009.09.004. Epub 2009 Dec 30.
The objective of this study was to investigate the relationship between the accumulation of black dust matter in lungs (anthracosis) and primary lung cancer in dogs. A retrospective study was carried out on material from 35 dogs with primary lung cancer and 160 controls. The amount, histological appearance and birefringence of anthracosis were assessed in pulmonary specimens by light microscopy, and the odds ratio (OR) calculated for dogs with primary lung cancer. The same factors were analysed to identify an association between tumour histotype, histological grade, and clinical stage. Papillary adenocarcinoma was most commonly diagnosed (45.7%). The majority of tumours were of histological grade II, and the lung cancer was more often localised (clinical stage I). An increased risk of lung cancer was observed in dogs with higher amounts of anthracosis (OR: 2.11, CI 95%: 1.20-3.70; P < 0.01), which suggests an association between anthracosis due to inhalation of polluted air and lung cancer in dogs.
本研究旨在探讨狗肺部黑尘物质（炭末沉着）蓄积与原发性肺癌之间的关系。对 35 例原发性肺癌犬和 160 例对照犬的材料进行了回顾性研究。通过光镜评估肺标本中的炭末沉着物的数量、组织学表现和双折射，并计算原发性肺癌犬的比值比（OR）。分析了相同的因素，以确定肿瘤组织类型、组织学分级和临床分期之间的关联。最常见的诊断是乳头状腺癌（45.7%）。大多数肿瘤的组织学分级为 II 级，肺癌更常局限于肺部（临床分期 I 期）。观察到炭末沉着量较高的犬患肺癌的风险增加（OR：2.11，95%CI：1.20-3.70；P<0.01），这表明由于吸入污染空气引起的炭末沉着与犬的肺癌之间存在关联。
