From the Departments of Otorhinolaryngology & Head and Neck Surgery.
Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
Clin Nucl Med. 2021 Apr 1;46(4):340-341. doi: 10.1097/RLU.0000000000003467.
Prostate-specific membrane antigen (PSMA) is expressed in the tumor-associated endothelial neovasculature of various nonprostatic benign and malignant neoplasms. A 25-year-old man with recurrent sinonasal glomangiopericytoma underwent whole-body 68Ga PSMA PET/CT to explore its theranostic role. There was intense PSMA uptake (SUVmax = 23.9) noted in the tumor. The uptake was more than that of the salivary glands, lacrimal glands, aorta, spleen, and the liver. Performance of PSMA PET/CT in sinonasal glomangiopericytoma opens up new frontiers concerning radiological imaging, early recurrence identification, and perhaps even radioligand therapy of residual/recurrent tumors.
前列腺特异性膜抗原 (PSMA) 表达于各种非前列腺良性和恶性肿瘤相关的肿瘤内皮新生血管中。一位 25 岁的复发性鼻腔鼻窦血管外皮细胞瘤患者接受了全身 68Ga PSMA PET/CT 检查，以探索其治疗作用。肿瘤中观察到强烈的 PSMA 摄取（SUVmax = 23.9）。摄取量高于唾液腺、泪腺、主动脉、脾脏和肝脏。PSMA PET/CT 在鼻腔鼻窦血管外皮细胞瘤中的应用为放射影像学、早期复发识别，甚至残留/复发性肿瘤的放射性配体治疗开辟了新的领域。
