Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan.
Retina. 2021 Jun 1;41(6):1219-1226. doi: 10.1097/IAE.0000000000003026.
To examine angiographic risk factors for the recurrence of macular edema associated with branch retinal vein occlusion.
We consecutively included 51 patients with treatment-naive branch retinal vein occlusion involving the macular area. Each eye initially received 3 monthly ranibizumab injections, with additional injections as necessary. At Month 3, we examined parafoveal vessel diameter indexes (VDI) in all sectors using optical coherence tomography angiography and determined the association with retinal thickness changes (Month 3-Month 5) and the number of ranibizumab injections during 12 months.
Parafoveal VDIs in the affected, nasal, and temporal sectors at Month 3 were significantly associated with corresponding parafoveal thickening (P = 0.020, 0.010, and <0.001, respectively), and the parafoveal VDIs in the affected and temporal sectors were significantly associated with future foveal thickening (P = 0.037, and 0.026, respectively). Moreover, the parafoveal VDI in the temporal sector showed a significant association with the total required number of ranibizumab injections (P = 0.040).
The parafoveal VDI may adequately represent the degree of congestion associated with branch retinal vein occlusion. Particularly, the VDI in the temporal sector may be a good predictor of future retinal thickening in the corresponding parafovea and the fovea and the number of ranibizumab injections.
探讨与分支静脉阻塞相关的黄斑水肿复发的血管造影危险因素。
我们连续纳入了 51 例累及黄斑区的未经治疗的分支静脉阻塞患者。每只眼最初接受 3 个月的雷珠单抗注射，必要时追加注射。在第 3 个月，我们使用光相干断层扫描血管造影检查所有象限的旁中心凹血管直径指数（VDI），并确定其与视网膜厚度变化（第 3 个月至第 5 个月）和 12 个月内雷珠单抗注射次数的关系。
第 3 个月时受影响、鼻侧和颞侧象限的旁中心凹 VDI 与相应的旁中心凹增厚显著相关（P = 0.020、0.010 和 <0.001），受影响和颞侧象限的旁中心凹 VDI 与未来中心凹增厚显著相关（P = 0.037 和 0.026）。此外，颞侧象限的旁中心凹 VDI 与雷珠单抗总注射次数显著相关（P = 0.040）。
旁中心凹 VDI 可充分代表分支静脉阻塞相关的充血程度。特别是，颞侧象限的 VDI 可能是对应旁中心凹和中心凹未来视网膜增厚以及雷珠单抗注射次数的良好预测指标。
