Kogo Takahiro, Muraoka Yuki, Ishikura Masaharu, Nishigori Naomi, Ueda-Arakawa Naoko, Miyata Manabu, Tamura Hiroshi, Hata Masayuki, Takahashi Ayako, Miyake Masahiro, Tsujikawa Akitaka
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Heliyon. 2023 Jul 22;9(8):e18441. doi: 10.1016/j.heliyon.2023.e18441. eCollection 2023 Aug.
To examine choroidal angiographic features in the posterior pole associated with resolution or persistency of subretinal fluid (SRF) in eyes with central serous chorioretinopathy (CSC).
Observational case series.
Twenty-nine patients with treatment-naïve CSC were divided into two groups based on the presence or absence of SRF 3 months after the initial visit (month 3) without any treatment. Using enhanced depth imaging of widefield swept-source optical coherence tomography, the choroidal thickness (CT), vessel density (VD), and vessel diameter index (VDI) in the superotemporal and inferotemporal subfields on the temporal side of the 18-mm circle from the disc were measured at the initial visit. We calculated the vertical difference in CT and other choroidal angiographic parameters and evaluated their association with the SRF condition at 3 months.
The SRF-resolved and SRF-persistent groups included 10 and 19 patients, respectively. At the initial visit, sex, age, axial length, symptom duration, the logarithm of the minimum angle of resolution visual acuity, and foveal thickness were not significantly different between the two groups. The SRF status at month 3 was not associated with the vertical difference in CT and choroidal VD ( = .614, .065, respectively). However, the vertical difference in choroidal VDI was positively associated with the future presence of SRF ( = .017).
Vertically asymmetric dilation of choroidal vessels in the posterior pole may be a vasculature feature associated with SRF from CSC and may be a good predictor of future SRF status.
研究中心性浆液性脉络膜视网膜病变（CSC）患者后极部脉络膜血管造影特征与视网膜下液（SRF）消退或持续存在的关系。
观察性病例系列。
29例未经治疗的CSC患者在初次就诊后3个月（第3个月）未接受任何治疗，根据是否存在SRF分为两组。使用超广角扫频源光学相干断层扫描的增强深度成像，在初次就诊时测量距视盘18mm圆周颞侧的颞上和颞下子区域的脉络膜厚度（CT）、血管密度（VD）和血管直径指数（VDI）。我们计算了CT和其他脉络膜血管造影参数的垂直差异，并评估它们与3个月时SRF状况的相关性。
SRF消退组和SRF持续组分别包括10例和19例患者。初次就诊时，两组在性别、年龄、眼轴长度、症状持续时间、最小分辨角视力的对数和黄斑厚度方面无显著差异。第3个月时的SRF状态与CT和脉络膜VD的垂直差异无关（分别为P = 0.614、0.065）。然而，脉络膜VDI的垂直差异与未来SRF的存在呈正相关（P = 0.017）。
后极部脉络膜血管垂直不对称扩张可能是与CSC所致SRF相关的血管特征，可能是未来SRF状态的良好预测指标。
