Department of Ophthalmology, Shinseikai Toyama Hospital, Imizu, Toyama, Japan.
Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan.
Sci Rep. 2021 Aug 6;11(1):15987. doi: 10.1038/s41598-021-95501-w.
We hypothesized the smoothness of the border between the inner nuclear layer (INL) and outer plexiform layer (OPL) associates with the frequency of macular edema (ME) recurrences secondary to branch retinal vein occlusion (BRVO). Thirty-seven consecutive eyes with BRVO treated with anti-vascular endothelial growth factor (VEGF) injections at 1-year follow-up were included. We manually traced the border between the INL and OPL within the 1.5-mm vertical line from the fovea on optical coherence tomography (OCT) images at the initial visit. The jagged ratio (JR), the border length divided by the spline curve length, was calculated. We performed univariate and multivariate regression analyses, including JR, patient characteristics, number of cystoid spaces in the INL, INL area, and outer retina area. Multivariate regression analysis showed JR significantly correlates with the total number of anti-VEGF injections (P < 0.0001). Moreover, the mean JR was significantly lower in the nine eyes receiving two or fewer injections than in the 28 eyes receiving three or more injections (1.02 ± 0.01 vs. 1.13 ± 0.06, P < 0.0001). A smooth border between the INL and the OPL on OCT images at the initial visit may be a biomarker for fewer ME recurrences in eyes with BRVO.
我们假设内核层（INL）和外丛状层（OPL）之间边界的平滑度与分支视网膜静脉阻塞（BRVO）继发的黄斑水肿（ME）复发频率有关。在 1 年的随访中，对 37 只接受抗血管内皮生长因子（VEGF）注射治疗的 BRVO 连续眼进行了研究。我们在初始就诊时的光学相干断层扫描（OCT）图像上，于黄斑中心凹下 1.5mm 垂直线内手动追踪 INL 和 OPL 之间的边界。计算锯齿比（JR），即边界长度除以样条曲线长度。我们进行了单变量和多变量回归分析，包括 JR、患者特征、INL 中囊状空间的数量、INL 面积和外视网膜面积。多变量回归分析表明，JR 与抗 VEGF 注射的总次数显著相关（P<0.0001）。此外，接受 2 次或更少注射的 9 只眼的平均 JR 明显低于接受 3 次或更多注射的 28 只眼（1.02±0.01 与 1.13±0.06，P<0.0001）。在初始就诊时的 OCT 图像上，INL 和 OPL 之间边界平滑可能是 BRVO 眼 ME 复发次数较少的生物标志物。
