Faculty of Science, University of Namur, Rue de Bruxelles, 61, Namur, Belgium.
Chem Commun (Camb). 2021 Jan 19;57(4):492-495. doi: 10.1039/d0cc07684h.
In this study, novel copillar[4+1]arenes were used as central heteromultivalent scaffolds via orthogonal couplings with a series of biologically relevant molecules such as carbohydrates, α-amino acids, biotin and phenylboronic acid. Further modifications by introducing maleimides or cyclooctyne groups provided molecular probes adapted to copper-free click chemistry. An octa-azidated fluorescent rotaxane bearing two distinct ligands was also generated in a fully controlled manner.
在这项研究中，新型的共轮烷[4+1]芳烃被用作中心杂多价支架，通过与一系列生物相关的分子（如碳水化合物、α-氨基酸、生物素和苯硼酸）进行正交偶联来实现。通过引入马来酰亚胺或环辛炔基团进一步修饰，提供了适应铜自由点击化学的分子探针。还以完全可控的方式生成了一种带有两个不同配体的八叠氮基荧光轮烷。
