Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China/ Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Medicine (Baltimore). 2020 Dec 11;99(50):e23622. doi: 10.1097/MD.0000000000023622.
Senile diabetes with depression is a common and frequently-occurring disease, and it is also a difficult and hot point in domestic and international research. However, the efficiency of combination hypoglycemic agents and antidepressants in the treatment of senile diabetes with depression is poor, and new intervention methods are urgently needed. Research shows the 5-element therapy, as a Chinese traditional non-drug intervention, has definite curative effect on the prevention and treatment of various physical and mental diseases. The purpose of this systematic review and meta-analysis is to evaluate the efficacy of 5-element therapy on senile diabetes with depression.
The electronic databases including Pubmed, Embase, Cochrane Library, Web of science, Chinese National Knowledge Infrastructure, Wanfang Database, Sino Med,China Biomedical Literature Database will be searched. The time limit for retrieving studies is from establishment to October 2020 for each database. Randomized controlled clinical trials related to 5-element therapy intervention on senile diabetes with depression will be included. Stata V.13.0 and Review manager 5.3 software will be implemented for data synthesis, sensitivity analysis, subgroup analysis, and the assessment of bias risk. We will use the grading of recommendations assessment, development, and evaluation system to assess the quality of evidence.
This study will provide a quantitative and standardized evaluation for the efficacy of 5-element therapy on senile diabetes with depression.
This systematic review and meta-analysis will provide the high-quality evidence to assess whether the 5-element therapy has a positive treatment effect for senile diabetes with depression.
INPLASY2020100081.
老年性糖尿病伴抑郁是一种常见且多发的疾病，也是国内外研究的难点和热点。但联合应用降糖药和抗抑郁药治疗老年性糖尿病伴抑郁的效果并不理想，急需新的干预手段。研究表明，五元素疗法作为一种中医非药物干预方法，对防治各种身心疾病具有确切疗效。本系统评价和荟萃分析旨在评估五元素疗法对老年性糖尿病伴抑郁的疗效。
检索 Pubmed、Embase、Cochrane 图书馆、Web of science、中国知网、万方数据库、中国生物医学文献数据库、Sino Med 等电子数据库，各数据库检索时间均从建库至 2020 年 10 月。纳入五元素疗法干预老年性糖尿病伴抑郁的随机对照临床试验。采用 Stata V.13.0 和 Review manager 5.3 软件进行数据合并、敏感性分析、亚组分析和偏倚风险评估。采用推荐评估、制定和评价系统的分级标准评估证据质量。
本研究将对五元素疗法治疗老年性糖尿病伴抑郁的疗效进行定量标准化评价。
本系统评价和荟萃分析将为评估五元素疗法对老年性糖尿病伴抑郁是否具有积极的治疗效果提供高质量的证据。
INPLASY2020100081。
