Jin Jun-O, Lee Geun Dong, Nam Sang Hee, Lee Tae Hyeong, Kang Dong Hoon, Yun Jae Kwang, Lee Peter Chang-Whan
Shanghai Public Health Clinical Center, Shanghai Medical College, Fudan University, Shanghai, 201508, China.
Department of Medical Biotechnology, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Cell Death Differ. 2021 Jun;28(6):1790-1803. doi: 10.1038/s41418-020-00701-y. Epub 2020 Dec 16.
Tripartite motif-containing 28 (TRIM28) is an E3 ubiquitin ligase harboring multiple cellular functions. We found that the TRIM28 protein is frequently overexpressed in patients with lung cancer. The stable overexpression of TRIM28 in lung cancer cells and xenograft models significantly increased the proliferation, migration, and invasiveness, whereas knockdown of TRIM28 had the opposite effect. We further observed that TRIM28 regulates the ubiquitin ligases RLIM and MDM2 to target the p53 levels during lung tumorigenesis. These data provide new insights into lung cancer development and potential new therapeutic targets for this disease.
含三联基序蛋白28（TRIM28）是一种具有多种细胞功能的E3泛素连接酶。我们发现TRIM28蛋白在肺癌患者中经常过度表达。在肺癌细胞和异种移植模型中稳定过表达TRIM28可显著增加细胞增殖、迁移和侵袭能力，而敲低TRIM28则产生相反的效果。我们进一步观察到，在肺癌发生过程中，TRIM28通过调节泛素连接酶RLIM和MDM2来靶向p53水平。这些数据为肺癌的发展提供了新的见解，并为该疾病提供了潜在的新治疗靶点。
