Campderrós Laura, Sánchez-Infantes David, Villarroya Joan, Nescolarde Lexa, Bayès-Genis Antoni, Cereijo Rubén, Roca Emma, Villarroya Francesc
Departament de Bioquimica i Biomedicina Molecular, University of Barcelona, Barcelona, Spain.
CIBER Fisiopatologia de la Obesidad y Nutrición, Madrid, Spain.
Front Physiol. 2020 Nov 19;11:550102. doi: 10.3389/fphys.2020.550102. eCollection 2020.
Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses of runners will help to discriminate individual race responsiveness and their physiological consequences. This study sought to analyze the changes in the plasma levels of GDF15 and FGF21, novel endocrine factors related to metabolic stress, in runners following the strenuous exercise of a marathon race.
Blood samples were obtained from eighteen male runners (mean ±SD, age: 41.7 ±5.0 years, BMI: 23.6 ± 1.8) 48 h before, immediately after, and 48 h after a marathon race, and from age-matched sedentary individuals. The level of GDF15, FGF21, and 38 additional biochemical and hematological parameters were determined.
The basal levels of GDF15 and FGF21 did not differ between runners before the race and sedentary individuals. Significant increases in the mean levels of GDF15 (4.2-fold) and FGF21 (20-fold) were found in runners immediately after the race. The magnitudes of these increases differed markedly among individuals and did not correlate with each other. The GDF15 and FGF21 levels had returned to the basal level 48 h post-race. The post-race value of GDF15 (but not FGF21) correlated positively with increased total white cell count ( = 0.50, = 0.01) and neutrophilia ( = 0.10, = 0.01).
GDF15 and FGF21 are transiently increased in runners following a marathon race. The induction of GDF15 levels is associated with alterations in circulating immune cells levels.
业余马拉松跑者面临巨大的生理挑战。评估潜在的生物标志物以了解跑者的生物学反应，将有助于区分个体的比赛反应及其生理后果。本研究旨在分析马拉松比赛剧烈运动后，跑者血浆中生长分化因子15（GDF15）和成纤维细胞生长因子21（FGF21）这两种与代谢应激相关的新型内分泌因子水平的变化。
在马拉松比赛前48小时、比赛结束后即刻以及比赛结束后48小时，采集了18名男性跑者（平均±标准差，年龄：41.7±5.0岁，体重指数：23.6±1.8）的血样，同时采集了年龄匹配的久坐不动个体的血样。测定了GDF15、FGF21以及另外38项生化和血液学参数的水平。
比赛前跑者与久坐不动个体的GDF15和FGF21基础水平无差异。比赛结束后即刻，跑者的GDF15平均水平显著升高（4.2倍），FGF21平均水平显著升高（20倍）。这些升高的幅度在个体间差异显著，且彼此不相关。GDF15和FGF21水平在比赛后48小时恢复到基础水平。比赛后GDF15的值（而非FGF21）与白细胞总数增加（r = 0.50，P = 0.01）和中性粒细胞增多（r = 0.10，P = 0.01）呈正相关。
马拉松比赛后跑者体内的GDF15和FGF2可短暂升高。GDF15水平的升高与循环免疫细胞水平的改变有关。
