Medicina NucleareIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro di Riferimento Oncologico della Basilicata (CROB)85028Rionero in VultureItaly.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche80145NapoliItaly.
IEEE J Transl Eng Health Med. 2020 Dec 2;9:2700306. doi: 10.1109/JTEHM.2020.3042118. eCollection 2021.
: To investigate the feasibility of using a wireless wearable device (WD) in differentiated thyroid cancer (DTC) patients undergoing radionuclide therapy with I-131 (RAI) and protected hospitalization, this study compared the measurements of residual radioactivity obtained with those registered by a permanent environmental home device (HD). : Twenty consecutive patients undergoing RAI hospitalized in restricted, controlled areas were enrolled. The patients underwent comprehensive monitoring of vital/nonvital parameters. We obtained 45580± 13 measurements from the WD, detecting the residual radioactivity for each patient during approximately 56 hours of hospitalization, collecting data 53 times per hour. The samples, collected during daily activities, were averaged every two hours, and the results correlated with those from the HD. Bland-Altman analysis was also used to evaluate the agreement between the two techniques. : A significant relationship between the WD and HD was observed (r = 0.96, p < 0.0001). Bland-Altman analysis recognized the agreement between measurements by the WD and HD. The mean value at the end of the first day of hospitalization was 80.81 microSv/h and 60.77 microSv/h (p = ns for WD and HD), whereas those at the end of the second day were 47.08 and 24.96 (p = ns). In the generalized linear model (GLM), a similar trend in performance across time was found with the two techniques. : This study demonstrates good agreement between the residual radioactivity measures estimated by the WD and HD modalities, rendering them interchangeable. This approach will allow both the optimization of medical staff exposure and safer patient discharge. : wireless device (WD); differentiated thyroid cancer (DTC); radionuclide therapy with I-131 (RAI); home device (HD); generalized linear model (GLM).
: 为了研究在接受 I-131（RAI）放射性核素治疗和保护性住院的分化型甲状腺癌（DTC）患者中使用无线可穿戴设备（WD）的可行性，本研究比较了 WD 测量的残留放射性与通过永久性家庭设备（HD）记录的测量值。 : 连续 20 例接受 RAI 治疗并住院于限制、控制区域的患者被纳入研究。患者接受了生命/非生命参数的全面监测。我们从 WD 获得了 45580±13 次测量，在大约 56 小时的住院期间对每个患者的残留放射性进行了检测，每小时收集 53 次数据。这些在日常活动中采集的样本每两小时平均一次，并将结果与 HD 进行了比较。Bland-Altman 分析也用于评估两种技术之间的一致性。 : WD 和 HD 之间存在显著的相关性（r=0.96，p<0.0001）。Bland-Altman 分析认可了 WD 和 HD 测量之间的一致性。住院第一天结束时的平均值分别为 80.81 微 Sv/h 和 60.77 微 Sv/h（WD 和 HD 之间的 p 值无统计学意义），而第二天结束时的平均值分别为 47.08 微 Sv/h 和 24.96 微 Sv/h（p 值无统计学意义）。在广义线性模型（GLM）中，发现两种技术在时间上的性能呈相似趋势。 : 本研究表明，WD 和 HD 两种模式估计的残留放射性之间具有良好的一致性，两者可以互换。这种方法将使医护人员的暴露得到优化，并使患者更安全地出院。 : 无线设备（WD）；分化型甲状腺癌（DTC）；I-131（RAI）放射性核素治疗；家庭设备（HD）；广义线性模型（GLM）。
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