PRP-HOM/SRBE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France.
Occup Environ Med. 2013 Sep;70(9):630-8. doi: 10.1136/oemed-2012-101149. Epub 2013 May 28.
The long-term effects of protracted low level ionising radiation exposure are investigated in a combined analysis of French nuclear workers employed by the Commissariat à l'Energie Atomique (CEA), AREVA Nuclear Cycle (AREVA NC) and Electricité de France (EDF). Associations between cumulative external radiation dose and mortality due to solid cancers, leukaemia and circulatory disease were examined.
All workers hired by CEA, AREVA NC and EDF between 1950 and 1994 who were employed for at least 1 year, badge-monitored for radiation exposure and alive on 1 January 1968 were included. Individual data of annual exposure to penetrating photons (X-rays and gamma rays) were reconstructed for each worker. Estimates of radiation dose-mortality associations were obtained using a linear excess relative risk (ERR) Poisson regression model.
Among the 59 021 nuclear workers, 2312 died of solid cancer, 78 of leukaemia and 1468 of circulatory diseases during the 1968-2004 period. Approximately 72% of the cohort had a non-zero cumulative radiation dose estimate, with a mean cumulative dose of 22.5 mSv. Positive but non-significant ERR/Sv were observed for all solid cancers, leukaemia excluding chronic lymphocytic leukaemia (CLL), ischaemic heart diseases and cerebrovascular diseases. A significant ERR/Sv was found for myeloid leukaemia.
This is the first combined analysis of major French cohorts of nuclear workers. Results were consistent with risks estimated in other nuclear worker cohorts and illustrate the potential of a further joint international study to yield direct risk estimates in support to radiation protection standards.
对法国核工业工人进行联合分析，以研究长时间低水平电离辐射暴露的长期影响。这些工人受雇于法国原子能委员会（CEA）、阿海珐核能公司（AREVA NC）和法国电力公司（EDF）。分析了累积外照射剂量与固体癌、白血病和循环系统疾病死亡率之间的关系。
该研究纳入了 1950 年至 1994 年间受雇于 CEA、AREVA NC 和 EDF、至少工作 1 年且佩戴辐射剂量计的所有工人，并且这些工人于 1968 年 1 月 1 日仍然存活。对每位工人的穿透性光子（X 射线和γ射线）的年暴露剂量进行个体数据重建。使用线性超额相对风险（ERR）泊松回归模型来评估剂量-死亡率关系。
在 59021 名核工业工人中，在 1968 年至 2004 年期间，有 2312 人死于固体癌，78 人死于白血病，1468 人死于循环系统疾病。大约 72%的队列具有非零的累积辐射剂量估计值，平均累积剂量为 22.5 mSv。所有固体癌、非慢性淋巴细胞白血病（CLL）白血病、缺血性心脏病和脑血管疾病的 ERR/Sv 呈正相关但无统计学意义。髓样白血病的 ERR/Sv 具有统计学意义。
这是首次对法国主要核工业工人队列进行的联合分析。结果与其他核工业工人队列估计的风险一致，表明进一步开展国际联合研究具有潜在价值，可以直接提供风险估计，以支持辐射防护标准。
