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合成代谢雄激素类固醇滥用所致失代偿性非缺血性心肌病

Decompensated Non-Ischemic Cardiomyopathy Induced by Anabolic-Androgenic Steroid Abuse.

作者信息

Sodhi Palwinder, Patel Meera R, Solsi Anup, Bellamkonda Pallavi

机构信息

Cardiology, Creighton University School of Medicine, St. Joseph's Hospital and Medical Center, Phoenix, USA.

Internal Medicine, Creighton University School of Medicine, St. Joseph's Hospital and Medical Center, Phoenix, USA.

出版信息

Cureus. 2020 Nov 13;12(11):e11476. doi: 10.7759/cureus.11476.

Abstract

A 30-year-old male presented to the emergency department with dyspnea, fatigue, orthopnea, and paroxysmal nocturnal dyspnea for the past three months. The patient admitted to anabolic steroid use for the past 11 years. Transthoracic echocardiography was significant for severely dilated left ventricle, diffuse hypokinesis, ejection fraction < 15%, and grade II diastolic dysfunction. The patient was diagnosed with decompensated, non-ischemic cardiomyopathy stage C, and New York Heart Classification (NYHA) class III > IV, likely from use of anabolic steroids, after a negative workup for other etiologies. On follow-up after continuation of guideline-directed medical therapy, the patient demonstrated improved heart failure status (NYHA class I > II). Cardiomyopathy is a rare but important adverse effect of anabolic steroids to consider.

摘要

一名30岁男性因过去三个月出现呼吸困难、乏力、端坐呼吸和阵发性夜间呼吸困难而就诊于急诊科。该患者承认在过去11年中使用过合成代谢类固醇。经胸超声心动图显示左心室严重扩张、弥漫性运动减弱、射血分数<15%以及II级舒张功能障碍。在排除其他病因的检查结果为阴性后,该患者被诊断为失代偿性、非缺血性C期心肌病,纽约心脏协会(NYHA)心功能分级为III>IV级,可能是由于使用合成代谢类固醇所致。在继续进行指南指导的药物治疗后的随访中,患者的心衰状况有所改善(NYHA心功能分级为I>II级)。心肌病是合成代谢类固醇一种罕见但重要的不良反应,需要加以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07b3/7734701/c5046eb85df0/cureus-0012-00000011476-i01.jpg

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