近红外二区半导体聚合物点用于深层组织荧光成像。
Near-Infrared-II Semiconducting Polymer Dots for Deep-tissue Fluorescence Imaging.
机构信息
Department of Applied Chemistry, National Chiao Tung University, Hsinchu, 30010, Taiwan.
Department of Materials Science and Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
出版信息
Chem Asian J. 2021 Feb 1;16(3):175-184. doi: 10.1002/asia.202001348. Epub 2020 Dec 28.
Fluorescence imaging, particularly in the NIR-II region (1000-1700 nm), has become an unprecedented tool for deep-tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical properties, ultrahigh brightness, minimal autofluorescence, narrow-size distribution, and low cytotoxicity. This review elucidates the recent advances in Pdots for deep-tissue fluorescence imaging and the facing future translation to clinical use.
荧光成像是一种强大的工具，尤其在近红外二区（1000-1700nm），它可以实现对深层组织的活体成像。在各种荧光纳米探针中，半导体聚合物纳米点（Pdots）因其可调谐的光学和光物理性质、超高的亮度、最小的自发荧光、窄的尺寸分布和低细胞毒性而成为一种很有前途的试剂。本文综述了 Pdots 在深层组织荧光成像方面的最新进展，并探讨了其未来向临床应用转化所面临的挑战。
Zotero 插件