Beijing Key Laboratory, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):11-19. doi: 10.1080/21691401.2020.1862134.
In this study, novel carbon dots (CDs) were discovered and separated from (AAFC) aqueous extract. AAFC-CDs were characterised by a series of methods, mainly including electron microscopy, optical technology and X-ray photoelectron spectroscopy (XPS). Results displayed that AAFC-CDs with a quantum yield (QY) around 0.19% had a size distribution between 6.0 and 10.0 nm and possessed a nearly spherical shape, with a lattice spacing of 0.369 nm. In mice, AAFC-CDs reduced the tissue damage, ear frostbite, and body stiffness caused by cold, and provided energy by increasing the use of blood glucose. The mechanism may be by decreasing concentration of IL-1βk, TNF-α and reducing the rise in blood glucose levels caused by frostbite. This study is the first to indicate that CDs may be the active constituent of AAFC against frostbite, suggesting their potential for clinical applications.
在这项研究中，从（AAFC）水提物中发现并分离出了新型碳点（CDs）。AAFC-CDs 通过一系列方法进行了表征，主要包括电子显微镜、光学技术和 X 射线光电子能谱（XPS）。结果表明，AAFC-CDs 的量子产率（QY）约为 0.19%，粒径分布在 6.0 至 10.0nm 之间，呈近球形，晶格间距为 0.369nm。在小鼠中，AAFC-CDs 减轻了寒冷引起的组织损伤、耳冻伤和身体僵硬，并通过增加血糖利用提供能量。其机制可能是通过降低 IL-1βk、TNF-α的浓度，并降低冻伤引起的血糖水平升高。本研究首次表明，CDs 可能是 AAFC 抗冻伤的活性成分，提示其在临床应用中的潜力。
