College of Bionanotechnology, Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Republic of Korea.
Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, Republic of Korea 55365.
Oxid Med Cell Longev. 2023 May 25;2023:3076119. doi: 10.1155/2023/3076119. eCollection 2023.
In recent decades, several studies demonstrating various applications of carbon dots (C-dots), including metal sensing, bioimaging, pH sensing, and antimicrobial activities, have been published. Recent developments have shifted this trend toward biomedical applications that target various biomarkers relevant to chronic diseases. However, relevant developments and research results regarding the anti-inflammatory properties of C-dots against inflammation-associated diseases have not been systematically reviewed. Hence, this review discusses the anti-inflammatory effects of C-dots in and models of LPS-induced inflammation, gout, cartilage tissue engineering, drug-induced inflammation, spinal cord injury, wound healing, liver diseases, stomach cancer, gastric ulcers, acute kidney and lung injury, psoriasis, fever or hypothermia, and bone tissue regeneration. The compiled studies demonstrate the promising potential of C-dots as anti-inflammatory agents for the development of new drugs.
近几十年来，已经发表了多项研究，展示了碳点（C-dots）的各种应用，包括金属感应、生物成像、pH 感应和抗菌活性。最近的发展趋势已经将这种趋势转向针对与慢性疾病相关的各种生物标志物的生物医学应用。然而，关于 C-dots 抗炎特性的相关发展和研究结果，针对炎症相关疾病的抗炎特性，尚未进行系统审查。因此，本综述讨论了 C-dots 在 LPS 诱导的炎症、痛风、软骨组织工程、药物诱导的炎症、脊髓损伤、伤口愈合、肝脏疾病、胃癌、胃溃疡、急性肾和肺损伤、银屑病、发热或低体温以及骨组织再生的体内和体外模型中的抗炎作用。汇编的研究表明，C-dots 作为抗炎药物在开发新药方面具有广阔的应用前景。
