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一种新型药物有望治疗高胆红素血症并预防高胆红素血症引起的肝损伤：源于. 的碳点

A Novel Drug with Potential to Treat Hyperbilirubinemia and Prevent Liver Damage Induced by Hyperbilirubinemia: Carbon Dots Derived from .

机构信息

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.

出版信息

Molecules. 2023 Mar 17;28(6):2720. doi: 10.3390/molecules28062720.

DOI:10.3390/molecules28062720
PMID:36985691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10056707/
Abstract

(PG) is a traditional Chinese medicine with a long history, but its active compounds have not been reported. In this study, novel carbon dots (CDs), PG-based CDs (PGC-CDs), were discovered and prepared from PG via calcinations and characterized by transmission electron microscopy; high-resolution transmission electron microscopy; X-ray diffraction, fluorescence, ultraviolet-visible, and Fourier-transform infrared spectrometers; X-ray photoelectron spectroscopy; and high-performance liquid chromatography. In addition, the safety and antioxidant activity of PGC-CDs was evaluated by RAW264.7 cells and LO2 cells. The therapeutic effects of PGC-CDs on hyperbilirubinemia and liver protection were evaluated in a bilirubin-induced hyperbilirubinemia mice model. The experiment confirmed that the diameter range of PGC-CDs was from 1.2 to 3.6 nm. PGC-CDs had no toxicity to RAW264.7 cells and LO2 cells at a concentration of 3.91 to 1000 µg/mL and could reduce the oxidative damage of cells caused by HO. PGC-CDs could inhibit the increase levels of bilirubin and inflammation factors and increase the levels of antioxidants and survival rate, demonstrating that PGC-CDs possessed anti-inflammatory and anti-oxidation activity. PGC-CDs may reduce the content of bilirubin, so as to reduce a series of pathological lesions caused by bilirubin, which has potential in treating hyperbilirubinemia and preventing liver damage induced by hyperbilirubinemia.

摘要

（PG）是一种历史悠久的中药，但它的活性化合物尚未被报道。在这项研究中，通过煅烧 PG 发现并制备了新型碳点（CDs），PG 基碳点（PGC-CDs），并通过透射电子显微镜；高分辨率透射电子显微镜；X 射线衍射、荧光、紫外可见和傅里叶变换红外光谱仪；X 射线光电子能谱；和高效液相色谱仪进行了表征。此外，通过 RAW264.7 细胞和 LO2 细胞评估了 PGC-CDs 的安全性和抗氧化活性。在胆红素诱导的高胆红素血症小鼠模型中评价了 PGC-CDs 对高胆红素血症和肝脏保护的治疗效果。实验证实，PGC-CDs 的直径范围为 1.2 至 3.6nm。PGC-CDs 在浓度为 3.91 至 1000μg/ml 时对 RAW264.7 细胞和 LO2 细胞没有毒性，并且可以减少 HO 引起的细胞氧化损伤。PGC-CDs 可以抑制胆红素和炎症因子水平的升高，增加抗氧化剂水平和存活率，表明 PGC-CDs 具有抗炎和抗氧化活性。PGC-CDs 可能降低胆红素含量，从而减少胆红素引起的一系列病理损伤，在治疗高胆红素血症和预防高胆红素血症引起的肝损伤方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/fbd9ab665800/molecules-28-02720-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/d7110db1da20/molecules-28-02720-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/fd03ca3e39b5/molecules-28-02720-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/be87aec4b44b/molecules-28-02720-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/e8fd6ded5030/molecules-28-02720-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/0db02d2b0903/molecules-28-02720-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/d0a7a5adbd09/molecules-28-02720-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/6d4d97433ac5/molecules-28-02720-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/9d2aac26ee09/molecules-28-02720-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/fbd9ab665800/molecules-28-02720-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/d7110db1da20/molecules-28-02720-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/fd03ca3e39b5/molecules-28-02720-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/be87aec4b44b/molecules-28-02720-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/e8fd6ded5030/molecules-28-02720-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/0db02d2b0903/molecules-28-02720-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/d0a7a5adbd09/molecules-28-02720-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/6d4d97433ac5/molecules-28-02720-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/9d2aac26ee09/molecules-28-02720-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4689/10056707/fbd9ab665800/molecules-28-02720-g009.jpg

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