Kersten W, Brade W
MMW Munch Med Wochenschr. 1979 Feb 16;121(7):247-50.
14 patients from the Allergy Unit of an outpatient clinic suffering from acute exacerbation of chronic bronchitis and 13 outpatients with acute bronchitis were treated with 250 mg cefaclor (Panoral) 3 times daily per os for 5 days. 59% of the organisms isolated from cefaclor-sensitive sputum at the time of prominent clinical symptoms were resistent to tetracycline, 53% of them were resistant to penicillin, and 37% were resistant to ampicillin. 12 out of the 14 patients with acute exacerbation of chronic bronchitis became asymptomatic, and no organisms could be detected in the sputum of 13 out of the same 14 patients two days after cessation of cefaclor treatment. In 12 out of the 13 patients with acute bronchitis, the acute clinical symptoms disappeared and in 11 out of the 13 patients the initial sputum organisms were two days after stopping cefaclor treatment.
一家门诊过敏科的14例慢性支气管炎急性加重患者和13例急性支气管炎门诊患者接受了口服头孢克洛(Panoral)250毫克、每日3次、共5天的治疗。在出现明显临床症状时,从对头孢克洛敏感的痰液中分离出的微生物,59%对四环素耐药,53%对青霉素耐药,37%对氨苄西林耐药。14例慢性支气管炎急性加重患者中有12例症状消失,在停止头孢克洛治疗两天后,这14例患者中的13例痰液中未检测到微生物。13例急性支气管炎患者中有12例急性临床症状消失,在停止头孢克洛治疗两天后,13例患者中有11例痰液中最初的微生物消失。