Xu Junzhong
Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, 37232, USA.
J Neurosci Methods. 2021 Feb 1;349:109024. doi: 10.1016/j.jneumeth.2020.109024. Epub 2020 Dec 14.
The detection sensitivity of diffusion MRI (dMRI) is dependent on diffusion times. A shorter diffusion time can increase the sensitivity to smaller length scales. However, the conventional dMRI uses the pulse gradient spin echo (PGSE) sequence that probes relatively long diffusion times only. To overcome this, the oscillating gradient spin echo (OGSE) sequence has been developed to probe much shorter diffusion times with hardware limitations on preclinical and clinical MRI systems. The OGSE sequence has been previously used on preclinical animal MRI systems. Recently, several studies have translated the OGSE sequence to humans on clinical MRI systems and achieved new information that is invisible using conventional PGSE sequence. This paper provides an overview of the recent progress of the OGSE neuroimaging in humans, including the technical improvements in the translation of the OGSE sequence to human imaging and various applications in different neurological disorders and stroke. Some possible future directions of the OGSE sequence are also discussed.
扩散磁共振成像（dMRI）的检测灵敏度取决于扩散时间。较短的扩散时间可提高对较小长度尺度的灵敏度。然而，传统的dMRI使用脉冲梯度自旋回波（PGSE）序列，该序列仅探测相对较长的扩散时间。为克服这一问题，已开发出振荡梯度自旋回波（OGSE）序列，以在临床前和临床MRI系统存在硬件限制的情况下探测更短的扩散时间。OGSE序列此前已用于临床前动物MRI系统。最近，一些研究已将OGSE序列应用于临床MRI系统中的人体，并获得了使用传统PGSE序列无法看到的新信息。本文概述了OGSE序列在人体神经成像方面的最新进展，包括将OGSE序列转化为人体成像的技术改进以及在不同神经系统疾病和中风中的各种应用。还讨论了OGSE序列未来可能的一些发展方向。
