Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, Institute of Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.
Laboratory of Aquatic Animal Nutrition and Feed, Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China.
Mar Drugs. 2020 Dec 15;18(12):642. doi: 10.3390/md18120642.
High-fat diet (HFD) usually induces oxidative stress and astaxanthin is regarded as an excellent anti-oxidant. An 8-week feeding trial was conducted to investigate the effects of dietary astaxanthin supplementation on growth performance, lipid metabolism, antioxidant ability, and immune response of juvenile largemouth bass () fed HFD. Four diets were formulated: the control diet (10.87% lipid, C), high-fat diet (18.08% lipid, HF), and HF diet supplemented with 75 and 150 mg kg astaxanthin (HFA1 and HFA2, respectively). Dietary supplementation of astaxanthin improved the growth of fish fed HFD, also decreased hepatosomatic index and intraperitoneal fat ratio of fish fed HFD, while having no effect on body fat. Malondialdehyde content and superoxide dismutase activity were increased in fish fed HFD, astaxanthin supplementation in HFD decreased the oxidative stress of fish. The supplementation of astaxanthin in HFD also reduced the mRNA levels of , , , and . These results suggested that dietary astaxanthin supplementation in HFD improved the growth performance, antioxidant ability and immune response of largemouth bass.
高脂肪饮食（HFD）通常会引起氧化应激，而虾青素被认为是一种优秀的抗氧化剂。本研究进行了为期 8 周的饲养试验，以研究饲料中添加虾青素对高脂肪饮食喂养的幼大口黑鲈生长性能、脂质代谢、抗氧化能力和免疫反应的影响。共配制了 4 种饲料：对照饲料（10.87%脂肪，C）、高脂肪饲料（18.08%脂肪，HF）和分别在高脂肪饲料中添加 75 和 150 mg/kg 虾青素的饲料（HFA1 和 HFA2）。虾青素的饲料添加改善了高脂肪饮食喂养的鱼类的生长，还降低了高脂肪饮食喂养的鱼类的肝体比和腹腔脂肪比，而对体脂没有影响。高脂肪饮食喂养的鱼类的丙二醛含量和超氧化物歧化酶活性增加，而高脂肪饮食中添加虾青素则降低了鱼类的氧化应激。在高脂肪饮食中添加虾青素还降低了 、 、 和 的 mRNA 水平。这些结果表明，在高脂肪饮食中添加虾青素可改善大口黑鲈的生长性能、抗氧化能力和免疫反应。
