Petitjean Max, Aussant Florian, Vergara Ainara, Isasi José Ramón
Department of Chemistry, University of Navarra, 31080 Pamplona, Spain.
Gels. 2020 Dec 15;6(4):51. doi: 10.3390/gels6040051.
The incorporation of cyclodextrins into polymeric crosslinked gels of hydrophilic nature can be useful for promoting the sorption of hydrophobic molecules and/or modulating the release of active principles. The covalent addition of these excipients to the matrix integrates their solubilizing effect that can contribute to increase the capacity of retention of hydrophobic substances. In this study, three diverse polysaccharides, chitosan, xanthan gum, and locust bean gum, were crosslinked with or without β-cyclodextrin, using citric acid in different ratios, to create hydrogel matrices. Through a green synthetic path, the efficient production of soluble and insoluble (hydrogel) networks functionalized with β-cyclodextrin was achieved by means of a solventless procedure. The characterization of their chemical composition, swelling in water, and their sorption and release behavior were also carried out in this work.
将环糊精掺入亲水性聚合物交联凝胶中，可能有助于促进疏水分子的吸附和/或调节活性成分的释放。将这些辅料共价添加到基质中，整合了它们的增溶作用，这有助于提高疏水物质的保留能力。在本研究中，使用不同比例的柠檬酸，将三种不同的多糖（壳聚糖、黄原胶和刺槐豆胶）与β-环糊精交联或不交联，以制备水凝胶基质。通过绿色合成路径，采用无溶剂程序，高效制备了用β-环糊精功能化的可溶性和不溶性（水凝胶）网络。在这项工作中，还对它们的化学成分、在水中的溶胀以及它们的吸附和释放行为进行了表征。
