光氧化还原催化实现了与高价碘（III）试剂的脱羧环化反应：通向2,5-二取代-1,3,4-恶二唑的方法。
Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles.
作者信息
Li Jian, Lu Xue-Chen, Xu Yue, Wen Jin-Xia, Hou Guo-Quan, Liu Li
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Pharmacy, Changzhou University, Changzhou 213164, China.
出版信息
Org Lett. 2020 Dec 18;22(24):9621-9626. doi: 10.1021/acs.orglett.0c03663. Epub 2020 Dec 1.
A novel approach to 2,5-disubstituted 1,3,4-oxadiazoles derivatives via a decarboxylative cyclization reaction by photoredox catalysis between commercially available α-oxocarboxylic acids and hypervalent iodine(III) reagent is described. This powerful transformation involves the coupling reaction between two different kinds of radical species and the formation of C-N and C-O bonds.
描述了一种通过光氧化还原催化在市售α-氧代羧酸与高价碘（III）试剂之间进行脱羧环化反应制备2,5-二取代-1,3,4-恶二唑衍生物的新方法。这种强大的转化涉及两种不同自由基物种之间的偶联反应以及C-N键和C-O键的形成。
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