School of Medical Sciences, Örebro University, Campus USÖ, S-701 82, Örebro, Sweden.
Department of Dermatology, Karlstad Central Hospital, Karlstad, Sweden.
BMC Dermatol. 2020 Dec 17;20(1):23. doi: 10.1186/s12895-020-00117-8.
The objective of this study was to investigate the relationships between atopic dermatitis (AD) and other common chronic health conditions in adults.
A cross-sectional survey was sent to a randomly selected population sample of 78,004 adults in Sweden. The questionnaires included measures of self-reported physical and mental health. Binary and multinomial logistic regression were used to examine the associations of AD with common chronic health conditions and psychological wellbeing.
AD was self-reported by 4,175 respondents, representing almost 14% of the study population of 34,313 adults. Our results showed positive associations between AD and chronic health disorders, including conditions of the oral cavity: chronic obstructive pulmonary disease (adjusted odds ratio [aOR] = 1.58, 95% confidence interval [CI]: 1.30 to 1.92), asthma (aOR = 2.13, 95% CI: 1.91 to 2.38), mild recurrent gastrointestinal symptoms (adjusted relative risk ratio [aRRR] = 1.78, 95% CI: 1.64 to 1.92), high blood pressure (aOR = 1.16, 95% CI: 1.06 to 1.26), obesity (aOR = 1.34, 95% CI: 1.23 to 1.47), mild joint pain (aRRR = 1.47, 95% CI: 1.35 to 1.61), mild headache or migraine (aRRR = 1.50, 95% CI: 1.38 to 1.64), caries (aOR = 1.25, 95% CI: 1.04 to 1.49), bleeding gums (aOR = 1.69, 95% CI: 1.38 to 2.08), periodontitis (aOR = 1.42, 95% CI: 1.13 to 1.77), sensitive teeth (aOR = 1.57, 95% CI: 1.35 to 1.82), and dry mouth (aOR = 1.52, 95% CI: 1.33 to 1.74). Adjustment for asthma and depression attenuated the magnitude of the associations between AD and the study outcomes. AD was also associated with poorer general psychological wellbeing.
Adults reporting AD may be at increased risk of chronic disorders and decreased psychological wellbeing. Physicians should recognize that individuals with severe AD and those with comorbid asthma or depression may be especially vulnerable.
本研究旨在探讨特应性皮炎（AD）与成年人其他常见慢性健康状况之间的关系。
一项横断面调查向瑞典 78004 名成年人的随机抽样人群发送了调查问卷。问卷包括对身体和心理健康的自我报告测量。采用二项和多项逻辑回归来检验 AD 与常见慢性健康状况和心理健康之间的关联。
AD 由 4175 名受访者自我报告，占研究人群中 34313 名成年人的近 14%。我们的研究结果表明，AD 与慢性健康障碍之间存在正相关，包括口腔疾病：慢性阻塞性肺疾病（调整后的优势比[aOR] = 1.58，95%置信区间[CI]：1.30 至 1.92）、哮喘（aOR = 2.13，95%CI：1.91 至 2.38）、轻度复发性胃肠道症状（调整后的相对风险比[aRRR] = 1.78，95%CI：1.64 至 1.92）、高血压（aOR = 1.16，95%CI：1.06 至 1.26）、肥胖（aOR = 1.34，95%CI：1.23 至 1.47）、轻度关节痛（aRRR = 1.47，95%CI：1.35 至 1.61）、轻度头痛或偏头痛（aRRR = 1.50，95%CI：1.38 至 1.64）、龋齿（aOR = 1.25，95%CI：1.04 至 1.49）、牙龈出血（aOR = 1.69，95%CI：1.38 至 2.08）、牙周炎（aOR = 1.42，95%CI：1.13 至 1.77）、牙齿敏感（aOR = 1.57，95%CI：1.35 至 1.82）和口干（aOR = 1.52，95%CI：1.33 至 1.74）。调整哮喘和抑郁因素后，AD 与研究结果之间的关联强度减弱。AD 还与一般心理健康较差有关。
报告患有 AD 的成年人可能面临更高的慢性疾病风险和较差的心理健康水平。医生应该认识到，严重 AD 患者以及合并哮喘或抑郁的患者可能特别脆弱。
