Yang Wei, Dai Hong, Xu Xiao-Feng, Jiang Hai-Yin, Ding Ji-Yuan
Department of Oncology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Neurol. 2024 Mar 21;15:1383832. doi: 10.3389/fneur.2024.1383832. eCollection 2024.
Growing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.
We systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in subjects with atopic dermatitis. Risk estimates from individual studies were pooled using random-effects models.
Ten studies with 12,717,747 subjects were included in the meta-analysis. Our results showed that patients with atopic dermatitis were associated with a higher risk of headache disorder (OR, 1.46, 95% CI = 1.36-1.56; < 0.001; I = 98%) or migraine (OR, 1.32, 95% CI = 1.18-1.47; < 0.001; I = 98.9%). Most of the results of the subgroup analyses were consistent with the overall results.
The findings of this meta-analysis suggest that atopic dermatitis is a potential risk indicator for headache disorder or migraine. Further studies are still needed to verify our findings due to the substantial heterogeneity in our analyses.
越来越多的证据表明，头痛性疾病和特应性皮炎具有相似的病理机制和风险因素。本研究的目的是评估特应性皮炎患者患头痛性疾病的风险。
我们系统检索了PubMed和Embase数据库，检索时间从数据库建立至2023年12月1日，查找关于研究特应性皮炎患者偏头痛风险的观察性研究。使用随机效应模型汇总各个研究的风险估计值。
荟萃分析纳入了10项研究，共12,717,747名受试者。我们的结果显示，特应性皮炎患者患头痛性疾病（比值比，1.46；95%置信区间=1.36 - 1.56；P<0.001；I² = 98%）或偏头痛（比值比，1.32；95%置信区间=1.18 - 1.47；P<0.001；I² = 98.9%）的风险更高。亚组分析的大多数结果与总体结果一致。
这项荟萃分析的结果表明，特应性皮炎是头痛性疾病或偏头痛的一个潜在风险指标。由于我们分析中存在大量异质性，仍需要进一步研究来验证我们的发现。
