Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan.
School of Medicine, China Medical University, Taichung, Taiwan.
J Investig Med. 2018 Oct;66(7):1064-1068. doi: 10.1136/jim-2018-000715. Epub 2018 Jun 14.
The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7-18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.
偏头痛与过敏之间的关联，一个多世纪以来一直存在争议。为了系统性地研究儿童期有过敏病史与他们日后在上学年龄发生偏头痛风险之间的相互作用，我们招募了 16130 名在 2000 年至 2008 年间被诊断患有偏头痛的年龄在 7-18 岁的儿童，以及 64520 名无偏头痛病史的匹配对照者。我们计算了在偏头痛诊断前诊断出的过敏病与偏头痛之间的关联的比值比 (OR)。过敏病包括特应性皮炎、过敏性结膜炎、过敏性鼻炎 (AR) 和哮喘。患有前驱过敏病的儿童发生偏头痛的后续风险高于对照组。在评估的四种疾病中，AR 的调整后比值比 (aOR) 最高，为 2.17（95%CI 2.09 至 2.26）。患有四种过敏病的儿童的 aOR 最高，为 3.59（95%CI 2.91 至 4.44）。此外，随着与过敏病相关的医疗咨询的增加，aOR 呈上升趋势。我们的研究表明，当儿童达到上学年龄时，患有过敏病的儿童发生偏头痛的后续风险增加，而且这种风险表现出更多过敏病和更多与过敏相关的医疗保健的累积效应。
