Nair Pratibha P, Nair Parvathy G, Pratap Shankar K M
National Ayurveda Research Institute for Panchakarma, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Cheruthuruthy, India.
National Ayurveda Research Institute for Panchakarma, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Cheruthuruthy, India.
J Ayurveda Integr Med. 2022 Jan-Mar;13(1):100351. doi: 10.1016/j.jaim.2020.08.004. Epub 2020 Sep 8.
The current COVID-19 pandemic brought about by the SARS-CoV-2, a novel β coronavirus is creating intense health havoc globally. Researchers suspect the situation to stay for long in the community, considering this virus's pathogenesis, high rate transmission and tendency to provoke uncontrolled immune response activation. Immune mechanisms are highly individualistic. We put forward a hypothetical model of prakruti (Ayurvedic body phenotyping character) based personalized prophylactic-therapeutic strategies aiming at a better immunomodulation and quicker resolution of host immune mechanisms. We propose this model in symptomatic, mild to moderate, COVID-19 diagnosed cases and in cases quarantined for high to low risk primary contact with a positive case. We also suggest a community level personalized Ayurvedic prophylactic-therapeutic strategy based on the DOTS model. Person-centered body purificatory measures (panchakarma procedures) like therapeutic purgation (virechana) and medicated enema (basti) are suggested in this hypothetical protocol with justification on evidence-based links between immune responses and prakruti along with specific jwara (fevers of varied origin as per Ayurvedic sciences) and COVID-19 symptomatology. The paper also appraises the importance of pitta dosha/ama dosha in the manifestation of inflammation driven destructive phase of immune responses along with its stage-wise intervention. This hypothetical model intends to open up discussions on significance of prakruti assessment as a predictive marker to screen people who are at risk of succumbing into deteriorating states if infected with COVID-19. It also intends to discuss the predictive personalized medicine measures based on prakruti in yielding individual host immune homeostasis which may positively reduce the chances of untoward events of an aggravated immune responsiveness and subsequent inflammation driven tissue destruction - the candidate causes for COVID-19 related casualties. Testing this model may give insight towards emphasizing personalized host immune coping mechanisms that may prove crucial in any infectious outbreaks in near future too.
由新型β冠状病毒严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的当前新冠疫情正在全球造成严重的健康破坏。考虑到这种病毒的发病机制、高传播率以及引发不受控制的免疫反应激活的倾向，研究人员怀疑这种情况将在社区中长期存在。免疫机制具有高度个体性。我们提出了一种基于体质（阿育吠陀身体表型特征）的假设模型，采用个性化的预防 - 治疗策略，旨在实现更好的免疫调节并更快地解决宿主免疫机制问题。我们在有症状的、轻度至中度的新冠确诊病例以及因与阳性病例有高风险至低风险的初次接触而被隔离的病例中提出此模型。我们还基于直接观察短程督导治疗（DOTS）模型提出了一种社区层面的个性化阿育吠陀预防 - 治疗策略。在这个假设方案中，建议采用以人为主的身体净化措施（五种疗法程序），如治疗性泻下（催吐疗法）和药浴灌肠（巴斯提疗法），并依据免疫反应与体质之间基于证据的联系以及特定的发热（根据阿育吠陀科学有多种起源的发热）和新冠症状学进行论证。本文还评估了火元素/毒素在炎症驱动的免疫反应破坏阶段表现中的重要性及其分阶段干预。这个假设模型旨在开启关于体质评估作为预测标志物的重要性的讨论，以筛选出如果感染新冠病毒就有陷入病情恶化状态风险的人群。它还打算讨论基于体质的预测性个性化医疗措施在实现个体宿主免疫稳态方面的作用，这可能会积极降低免疫反应加剧和随后炎症驱动的组织破坏这些不良事件的发生几率，而这些正是新冠相关伤亡的潜在原因。对这个模型进行测试可能有助于深入了解强调个性化宿主免疫应对机制的重要性，这在不久的将来应对任何传染病爆发时可能也至关重要。
