利什曼病中巨噬细胞亚群和细胞因子产生的调控。
Regulation of macrophage subsets and cytokine production in leishmaniasis.
机构信息
Snyder Institute for Chronic Diseases, Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada; Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
出版信息
Cytokine. 2021 Nov;147:155309. doi: 10.1016/j.cyto.2020.155309. Epub 2020 Dec 14.
Macrophages are host cells for parasites of the genus Leishmania where they multiply inside parasitophorous vacuoles. Paradoxically, macrophages are also the cells responsible for killing or controlling parasite growth, if appropriately activated. In this review, we will cover the patterns of macrophage activation and the mechanisms used by the parasite to circumvent being killed. We will highlight the impacts of the vector bite on macrophage activation. Finally, we will discuss the ontogeny of macrophages that are infected by Leishmania spp.
巨噬细胞是利什曼原虫属寄生虫的宿主细胞，寄生虫在吞噬泡内繁殖。矛盾的是，如果巨噬细胞得到适当激活，它们也是负责杀死或控制寄生虫生长的细胞。在这篇综述中，我们将介绍巨噬细胞激活的模式和寄生虫用来避免被杀死的机制。我们将强调媒介叮咬对巨噬细胞激活的影响。最后，我们将讨论被利什曼原虫属感染的巨噬细胞的个体发生。
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