Kane M M, Mosser D M
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Curr Opin Hematol. 2000 Jan;7(1):26-31. doi: 10.1097/00062752-200001000-00006.
Leishmania are intracellular protozoan parasites of macrophages. At the cellular level, the disease leishmaniasis involves the invasion of tissue macrophages by the parasite, the avoidance of cellular killing mechanisms, and the subsequent intracellular replication of parasites, with the eventual spread of the organisms to adjacent macrophages. This paper describes the process by which Leishmania organisms invade macrophages, with an overview of some of the molecules involved in this process; the mechanisms available to macrophages that have the potential to restrict the growth of Leishmania within them; and the ways that Leishmania and Leishmania-derived molecules can modulate macrophage functions and circumvent leukocyte antimicrobial responses.
利什曼原虫是巨噬细胞内的原生动物寄生虫。在细胞水平上，利什曼病涉及寄生虫对组织巨噬细胞的侵袭、逃避细胞杀伤机制以及随后寄生虫在细胞内的复制，最终病原体扩散到相邻的巨噬细胞。本文描述了利什曼原虫侵入巨噬细胞的过程，概述了该过程中涉及的一些分子；巨噬细胞可用于限制利什曼原虫在其内部生长的机制；以及利什曼原虫和利什曼原虫衍生分子调节巨噬细胞功能和规避白细胞抗菌反应的方式。
