在具有杀利什曼原虫活性的喹啉类化合物中，碱性和亲脂性链基团对于促进吞噬溶酶体积累是否是高度必需的？ - Suppr

Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation?

作者信息

Romero Angel H

机构信息

Grupo de Química Orgánica Medicinal, Instituto de Quimica-Biologica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay.

出版信息

Front Chem. 2025 Aug 21;13:1655979. doi: 10.3389/fchem.2025.1655979. eCollection 2025.

DOI:10.3389/fchem.2025.1655979

PMID:40919240

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12408622/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90f/12408622/f26e8f4585d1/FCHEM_fchem-2025-1655979_wc_sch1.jpg

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Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation?

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