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与结直肠腹膜转移相关的DNA和RNA改变：一项系统综述

DNA and RNA Alterations Associated with Colorectal Peritoneal Metastases: A Systematic Review.

作者信息

Heuvelings Danique J I, Wintjens Anne G W E, Luyten Julien, Wilmink Guus E W A, Moonen Laura, Speel Ernst-Jan M, de Hingh Ignace H J T, Bouvy Nicole D, Peeters Andrea

机构信息

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.

Department of General Surgery, Maastricht University Medical Center (MUMC+), 6202 AZ Maastricht, The Netherlands.

出版信息

Cancers (Basel). 2023 Jan 16;15(2):549. doi: 10.3390/cancers15020549.

DOI:10.3390/cancers15020549
PMID:36672497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9856984/
Abstract

BACKGROUND

As colorectal cancer (CRC) patients with peritoneal metastases (PM) have a poor prognosis, new treatment options are currently being investigated for CRC patients. Specific biomarkers in the primary tumor could serve as a prediction tool to estimate the risk of distant metastatic spread. This would help identify patients eligible for early treatment.

AIM

To give an overview of previously studied DNA and RNA alterations in the primary tumor correlated to colorectal PM and investigate which gene mutations should be further studied.

METHODS

A systematic review of all published studies reporting genomic analyses on the primary tissue of CRC tumors in relation to PM was undertaken according to PRISMA guidelines.

RESULTS

Overall, 32 studies with 18,906 patients were included. mutations were analyzed in 17 articles, of which 10 found a significant association with PM. For all other reported genes, no association with PM was found. Two analyses with broader cancer panels did not reveal any new biomarkers.

CONCLUSION

An association of specific biomarkers in the primary tumors of CRC patients with metastatic spread into peritoneum could not be proven. The role of mutations should be further investigated. In addition, studies searching for potential novel biomarkers are still required.

摘要

背景

由于结直肠癌（CRC）伴腹膜转移（PM）患者预后较差，目前正在为CRC患者研究新的治疗方案。原发肿瘤中的特定生物标志物可作为预测工具，以估计远处转移扩散的风险。这将有助于识别适合早期治疗的患者。

目的

概述先前研究的与结直肠癌PM相关的原发肿瘤中的DNA和RNA改变，并研究哪些基因突变应进一步研究。

方法

根据PRISMA指南，对所有已发表的报告结直肠癌肿瘤原发组织与PM相关的基因组分析的研究进行系统综述。

结果

总共纳入了32项研究，涉及18906名患者。在17篇文章中分析了突变，其中10篇发现与PM有显著关联。对于所有其他报告的基因，未发现与PM有关联。两项使用更广泛癌症面板的分析未发现任何新的生物标志物。

结论

无法证实CRC患者原发肿瘤中的特定生物标志物与转移至腹膜之间存在关联。应进一步研究突变的作用。此外，仍需要寻找潜在新生物标志物的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/511784a51844/cancers-15-00549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/f669a94919a9/cancers-15-00549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/e9e3edc6b9d6/cancers-15-00549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/f8954436e01c/cancers-15-00549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/ce6540099dca/cancers-15-00549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/2492ac12e7e7/cancers-15-00549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/511784a51844/cancers-15-00549-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/f669a94919a9/cancers-15-00549-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/e9e3edc6b9d6/cancers-15-00549-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/f8954436e01c/cancers-15-00549-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/ce6540099dca/cancers-15-00549-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/2492ac12e7e7/cancers-15-00549-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0407/9856984/511784a51844/cancers-15-00549-g006.jpg

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