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Potentially toxic elements in the brains of people with multiple sclerosis.多发性硬化症患者大脑中的潜在有毒元素。
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本文引用的文献

1
Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.细胞类型特异性基因内相互作用揭示多发性硬化症中的少突胶质细胞机制。
Cell. 2020 Apr 16;181(2):382-395.e21. doi: 10.1016/j.cell.2020.03.002. Epub 2020 Apr 3.
2
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.多发性硬化症基因组图谱提示外周免疫细胞和小胶质细胞与易感性有关。
Science. 2019 Sep 27;365(6460). doi: 10.1126/science.aav7188.
3
Multiple Sclerosis patients carry an increased burden of exceedingly rare genetic variants in the inflammasome regulatory genes.多发性硬化症患者携带炎症小体调节基因中极其罕见的遗传变异的负担增加。
Sci Rep. 2019 Jun 24;9(1):9171. doi: 10.1038/s41598-019-45598-x.
4
Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease.外显子组测序在多发性硬化症家族中鉴定出 12 个候选基因，并提名了疾病发生的生物学途径。
PLoS Genet. 2019 Jun 6;15(6):e1008180. doi: 10.1371/journal.pgen.1008180. eCollection 2019 Jun.
5
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk.低频和罕见编码变异导致多发性硬化症风险增加。
Cell. 2018 Nov 29;175(6):1679-1687.e7. doi: 10.1016/j.cell.2018.09.049. Epub 2018 Oct 18.
6
Multiple Sclerosis Pathology.多发性硬化症病理学。
Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a028936. doi: 10.1101/cshperspect.a028936.
7
Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis: the impact of genome-wide association studies identified disease risk loci.醋酸格拉替雷治疗多发性硬化症的药物遗传学：全基因组关联研究确定的疾病风险位点的影响。
Pharmacogenomics. 2017 Nov;18(17):1563-1574. doi: 10.2217/pgs-2017-0058. Epub 2017 Nov 2.
8
A pharmacogenetic signature of high response to Copaxone in late-phase clinical-trial cohorts of multiple sclerosis.多发性硬化症晚期临床试验队列中对考帕松高反应的药物遗传学特征。
Genome Med. 2017 May 31;9(1):50. doi: 10.1186/s13073-017-0436-y.
9
Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study.多发性硬化症患者对β-干扰素治疗的反应：一项全基因组关联研究。
Pharmacogenomics J. 2017 Jul;17(4):312-318. doi: 10.1038/tpj.2016.20. Epub 2016 Mar 22.
10
Multiple sclerosis prevalence in the United States commercially insured population.美国商业保险人群中的多发性硬化症患病率。
Neurology. 2016 Mar 15;86(11):1014-21. doi: 10.1212/WNL.0000000000002469. Epub 2016 Feb 17.

Involvement of Genetic Factors in Multiple Sclerosis.

作者信息

Ferrè Laura, Filippi Massimo, Esposito Federica

机构信息

Neurology Unit, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy.

Neurorehabilitation Unit, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy.

出版信息

Front Cell Neurosci. 2020 Dec 1;14:612953. doi: 10.3389/fncel.2020.612953. eCollection 2020.

DOI:10.3389/fncel.2020.612953
PMID:33335478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7735985/
Abstract
摘要