人工对称蛋白质的开发与应用
Development and applications of artificial symmetrical proteins.
作者信息
Vrancken Jeroen P M, Tame Jeremy R H, Voet Arnout R D
机构信息
Laboratory of Biomolecular Modelling and Design, Department of Chemistry, KU Leuven, Celestijnenlaan 200G, 3001 Leuven, Belgium.
Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro, Yokohama, Kanagawa 230-0045, Japan.
出版信息
Comput Struct Biotechnol J. 2020 Nov 27;18:3959-3968. doi: 10.1016/j.csbj.2020.10.040. eCollection 2020.
Since the determination of the first molecular models of proteins there has been interest in creating proteins artificially, but such methods have only become widely successful in the last decade. Gradual improvements over a long period of time have now yielded numerous examples of non-natural proteins, many of which are built from repeated elements. In this review we discuss the design of such symmetrical proteins and their various applications in chemistry and medicine.
自从确定了蛋白质的第一个分子模型以来，人们就对人工合成蛋白质产生了兴趣，但这种方法直到最近十年才广泛取得成功。经过长时间的逐步改进，现在已经产生了许多非天然蛋白质的例子，其中许多是由重复元件构建而成的。在这篇综述中，我们讨论了这类对称蛋白质的设计及其在化学和医学中的各种应用。
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