Jang Sung Ho, Kim Seong Ho, Seo You Sung
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, 317-1, Daemyungdong, Namku, Taegu, 705-717, Republic of Korea.
Department of Neurosurgery, College of Medicine Yeungnam University, 317-1, Daemyungdong, Namku, Taegu, 705-717, Republic of Korea.
Transl Neurosci. 2020 Sep 21;11(1):335-340. doi: 10.1515/tnsci-2020-0108. eCollection 2020.
We investigated injuries of the optic radiations (ORs) in patients with mild traumatic brain injury (TBI) by using diffusion tensor tractography (DTT).
Fifty-two consecutive patients who complained of visual problems showed abnormal visual evoked potential (VEP) latency but no abnormality on conventional brain MRI after mild TBI, and fifty normal control subjects were recruited for this study. Subjects' ORs were reconstructed using DTT, and three DTT parameters (fractional anisotropy [FA], apparent diffusion coefficient [ADC], and tract volume) were measured for each OR.
Mean FA value and tract volume of the OR were significantly lower in the patient group than in the control group ( < 0.05). However, there was no significant difference in the ADC values of the OR between the patient and control groups ( > 0.05). A weak negative correlation was detected between VEP latency and OR fiber number ( = 0.204, < 0.05).
DTT revealed that OR injuries were not detected on the conventional brain MRI scans of patients who complained of visual problems and had abnormal VEP latency after mild TBI. Our results suggest that DTT would be a useful technique for detecting OR injury in patients with mild TBI.
我们采用弥散张量纤维束成像（DTT）研究轻度创伤性脑损伤（TBI）患者的视辐射（ORs）损伤情况。
52例连续的主诉有视觉问题的患者，在轻度TBI后视觉诱发电位（VEP）潜伏期异常，但常规脑MRI无异常，另外招募50名正常对照者参与本研究。使用DTT重建受试者的ORs，并测量每个OR的三个DTT参数（分数各向异性[FA]、表观扩散系数[ADC]和纤维束体积）。
患者组OR的平均FA值和纤维束体积显著低于对照组（<0.05）。然而，患者组与对照组ORs的ADC值无显著差异（>0.05）。VEP潜伏期与OR纤维数量之间存在弱负相关（=0.204，<0.05）。
DTT显示，在轻度TBI后主诉有视觉问题且VEP潜伏期异常的患者的常规脑MRI扫描中未检测到OR损伤。我们的结果表明，DTT将是检测轻度TBI患者OR损伤的一种有用技术。
