miRNAs 在成瘾的病理生理学中的作用。
Role of microRNAs in the pathophysiology of addiction.
机构信息
Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
出版信息
Wiley Interdiscip Rev RNA. 2021 May;12(3):e1637. doi: 10.1002/wrna.1637. Epub 2020 Dec 17.
Abstract
Addiction is a chronic and relapsing brain disorder characterized by compulsive seeking despite adverse consequences. There are both heritable and epigenetic mechanisms underlying drug addiction. Emerging evidence suggests that non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long non-coding RNAs, and circular RNAs regulate synaptic plasticity and related behaviors caused by substances of abuse. These ncRNAs modify gene expression and may contribute to the behavioral phenotypes of addiction. Among the ncRNAs, the most widely researched and impactful are miRNAs. The goal in this systematic review is to provide a detailed account of recent research involving the role of miRNAs in addiction. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions RNA in Disease and Development > RNA in Disease.
摘要
成瘾是一种慢性且易复发的大脑障碍，其特征是尽管存在不良后果，但仍存在强迫性寻求。成瘾有遗传和表观遗传机制。新出现的证据表明，非编码 RNA（ncRNA），如 microRNAs（miRNAs）、长非编码 RNA 和环状 RNA 调节药物滥用引起的突触可塑性和相关行为。这些 ncRNA 修饰基因表达，并可能导致成瘾的行为表型。在这些 ncRNA 中，研究最多且最有影响力的是 miRNAs。本系统评价的目的是详细描述 miRNA 在成瘾中的作用的最新研究。本文归类于：RNA 与蛋白质和其他分子的相互作用>小分子-RNA 相互作用 RNA 在疾病与发展中的作用>RNA 在疾病中的作用。
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