Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
Nanoscale. 2021 Jan 7;13(1):131-137. doi: 10.1039/d0nr07681c. Epub 2020 Dec 18.
Despite the increasing usage of porphyrinic metal-organic frameworks (MOFs) for combination therapy, the controlled encapsulation of inorganic nanoparticle-based therapeutics into such MOFs with specific structures has remained a major obstacle for improved tumor therapy. Here, we report the synthesis of a mesoporous MOF shell on the surface of gold nanorods (AuNRs), wherein a single AuNR is captured individually in single-crystalline MOFs with a controlled crystallographic orientation, for combinational phototherapy against solid tumors. The core-shell heterostructures have the benefits of a mesoporous structure and photoinduced singlet oxygen generation behavior characterized by the porphyrinic MOF shell, together with the plasmonic photothermal conversion characteristic of AuNRs. We demonstrated that the AuNR@MOF nanoplatform enables an efficient tumor treatment strategy by combining photodynamic therapy and photothermal therapy. We should emphasize that such systems could have applications beyond the field of cancer therapy, like plasmonic harvesting of light energy to induce and accelerate catalytic reactions within MOFs and multifunctional nanocarriers for agricultural formulations.
尽管卟啉金属-有机骨架（MOFs）在联合治疗中的应用日益广泛，但将基于无机纳米颗粒的治疗药物精确地封装到具有特定结构的 MOFs 中仍然是提高肿瘤治疗效果的主要障碍。在这里，我们报告了在金纳米棒（AuNRs）表面合成介孔 MOF 壳的方法，其中单个 AuNR 被单独捕获在具有受控晶面取向的单晶 MOFs 中，用于针对实体瘤的联合光疗。核壳异质结构具有介孔结构和由卟啉 MOF 壳表现出的光诱导单线态氧生成行为的优点，以及 AuNR 的等离子体光热转换特性。我们证明，AuNR@MOF 纳米平台通过结合光动力疗法和光热疗法实现了有效的肿瘤治疗策略。我们应该强调的是，这种系统的应用可能不仅限于癌症治疗领域，例如通过等离子体收集光能来在 MOFs 内诱导和加速催化反应，以及用于农业制剂的多功能纳米载体。
