Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy.
Eur Rev Med Pharmacol Sci. 2020 Dec;24(23):12267-12287. doi: 10.26355/eurrev_202012_24019.
Helicobacter pylori is a Gram-negative bacterium identified for the first time about 30 years ago and commonly considered as the main pathogenic factor of gastritis and peptic ulcer. Since then, it was found to be associated with several gastrointestinal and extra-gastrointestinal diseases. Helicobacter pylori is also associated with many skin disorders including, but not limited to, chronic urticaria, rosacea, lichen planus, atopic dermatitis, psoriasis, pemphigus vulgaris, vitiligo, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, primary cutaneous marginal zone B-cell lymphomas and cutaneous T-cell pseudolymphoma. Literature up to September 2020 shows that clear evidence exists only for some of the mentioned associations, while in the majority of cases, data appear contrasting. The aim of this review is to summarize the available studies on the topic and draw possible conclusions. Further clinical and laboratory studies are needed to assess the real plausibility and relevance of these associations, as well as the possible role of Helicobacter pylori with the underlying pathogenic mechanisms.
幽门螺杆菌是一种革兰氏阴性细菌，大约 30 年前首次被发现，通常被认为是胃炎和消化性溃疡的主要致病因素。从那时起，人们发现它与多种胃肠道和胃肠道外疾病有关。幽门螺杆菌还与多种皮肤疾病有关，包括但不限于慢性荨麻疹、酒渣鼻、扁平苔藓、特应性皮炎、银屑病、寻常型天疱疮、白癜风、原发性皮肤黏膜边缘区 B 细胞淋巴瘤和亚层致密型线性 IgA 大疱性皮病。截至 2020 年 9 月的文献表明，仅对其中一些关联存在明确证据，而在大多数情况下，数据似乎相互矛盾。本综述的目的是总结关于该主题的现有研究并得出可能的结论。需要进一步的临床和实验室研究来评估这些关联的真正可能性和相关性，以及幽门螺杆菌在潜在发病机制中的可能作用。
