Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997, Moscow, Russia.
Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow, 117997, Russia.
Chemistry. 2021 Feb 24;27(12):3986-3990. doi: 10.1002/chem.202004760. Epub 2021 Feb 2.
Using benzylidene imidazolone core, we created a panel of color-shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live-cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live-cell fluorogenic labeling tools.
我们使用亚苄基咪唑啉酮核心，为 FAST 蛋白创建了一组颜色位移的荧光配体，在不影响结合效率和用于活细胞蛋白标记的实用性的情况下做到了这一点。这项研究强调了亚苄基咪唑啉酮衍生物在快速扩展活细胞荧光标记工具库方面的潜力。
