肥胖相关认知障碍：内皮功能障碍的作用。
Obesity-related cognitive impairment: The role of endothelial dysfunction.
机构信息
WISSDOM Center, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.
Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA; Molecular and Cellular Biology and Pathobiology Program, Medical University of South Carolina, Charleston, SC 29425, USA.
出版信息
Neurobiol Dis. 2019 Dec;132:104580. doi: 10.1016/j.nbd.2019.104580. Epub 2019 Aug 24.
Abstract
Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical and preclinical studies supporting a role for obesity in cognitive impairment. Next, we discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, and gut dysbiosis lead to cognitive impairment through induction of endothelial dysfunction and disruption of the blood brain barrier. Finally, we outline the potential clinical utility of dietary interventions, exercise, and bariatric surgery in circumventing the impacts of obesity on cognitive function.
摘要
肥胖是一种全球性的大流行疾病，与大血管和微血管内皮功能障碍有关。微血管内皮功能障碍最近已成为认知障碍发展的一个重要危险因素。在这篇综述中，我们提供了临床和临床前研究的证据，支持肥胖与认知障碍有关。接下来，我们讨论了肥胖相关的高胰岛素血症/胰岛素抵抗、全身炎症和肠道菌群失调如何通过诱导内皮功能障碍和破坏血脑屏障导致认知障碍。最后，我们概述了饮食干预、运动和减肥手术在避免肥胖对认知功能影响方面的潜在临床应用。
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