Universidade Federal de Pernambuco, Departamento de Medicina Tropical, Recife, PE, Brasil.
Instituto Aggeu Magalhães, Laboratório de Biologia Molecular e Celular, Departamento de Parasitologia, Recife, PE, Brasil.
Rev Soc Bras Med Trop. 2020 Dec 21;54:e02622020. doi: 10.1590/0037-8682-0262-2020. eCollection 2020.
Carbapenemase-resistant enterobacteria that produce the bla NDM gene are found worldwide. However, this is the first report of blaNDM in Klebsiella aerogenes in Brazil.
The identification of bacterial species was performed using anautomated system and confirmed by biochemical tests, 16S rRNA gene sequencing, and detection of resistance genes.
The clinical isolate showed minimum inhibitory concentration resistance to meropenem and polymyxin B at 8mg/L and 4mg/L, respectively. Only the blaNDM gene was detected.
The current report of the blaNDM gene in isolated MDR enterobacteria indicates that this gene can spread silently in a hospital setting.
产生 blaNDM 基因的耐碳青霉烯肠杆菌在世界范围内都有发现。然而，这是 blaNDM 基因在巴西产气肠杆菌中的首次报告。
细菌种类的鉴定使用自动化系统进行，并通过生化试验、16S rRNA 基因测序和耐药基因检测进行确认。
临床分离株对美罗培南和多粘菌素 B 的最小抑菌浓度分别为 8mg/L 和 4mg/L，表现出耐药性。仅检测到 blaNDM 基因。
目前在多药耐药肠杆菌中分离到 blaNDM 基因的报告表明，该基因可以在医院环境中悄然传播。
