Institute of Reproductive and Child Health, Peking University/ Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China.
Jiangxi Environmental Engineering Vocational College, Ganzhou City, 341002, PR China.
Chemosphere. 2021 Mar;267:129146. doi: 10.1016/j.chemosphere.2020.129146. Epub 2020 Nov 29.
The effects of ambient fine particulate matter (PM) exposure on blood pressure have been widely reported. However, there remains uncertainty regarding the underlying roles of particulate matter components. We aimed to investigate the association between ambient PM exposure and blood pressure, as well as the potential effects of trace metal(loid)s, in a repeated-measurement study that enrolled women of childbearing age. Our study included 35 participants from Hebei Province, China, each of whom was visited for five times. During each visit, we conducted questionnaire surveys, measured blood pressure, and collected blood. The daily PM exposure of participants was estimated according to their residential addresses using a spatiotemporal model that combined monitoring data with satellite measurements and chemical-transport model simulations. This model was used to calculate average PM concentrations in 1, 3, 7, 15, 30, and 60 days prior to each visit. Serum concentrations of various trace metal(loid)s were measured. A linear mixed-effects model was used to investigate associations among study variables. Overall, the mean (standard deviation) 60 days PM concentration over all five visits was 108.1(43.3) μg/m. PM concentration was positively associated with both systolic and diastolic blood pressures. Likewise, ambient PM concentration was positively associated with serum concentrations of manganese and arsenic, and negatively associated with serum concentrations of nickel, tin, and chromium. Only the serum concentration of molybdenum was negatively associated with systolic blood pressure. We concluded that ambient PM exposure may contribute to elevated blood pressure, potentially by interfering with internal intake of various metal(loid)s in the human body.
大气细颗粒物（PM）暴露对血压的影响已被广泛报道。然而，对于颗粒物成分的潜在作用仍存在不确定性。我们旨在通过一项重复测量研究，调查大气 PM 暴露与血压之间的关系，以及痕量金属（类）物质的潜在影响，该研究纳入了育龄妇女。我们的研究包括来自中国河北省的 35 名参与者，每位参与者被访视了 5 次。在每次访视中，我们进行问卷调查、测量血压并采集血液。根据参与者的居住地址，使用时空模型结合监测数据、卫星测量和化学传输模型模拟来估计参与者的每日 PM 暴露量。该模型用于计算每次访视前 1、3、7、15、30 和 60 天的平均 PM 浓度。测量了各种痕量金属（类）物质的血清浓度。使用线性混合效应模型研究研究变量之间的关联。总体而言，五次访视的平均（标准差）60 天 PM 浓度为 108.1（43.3）μg/m。PM 浓度与收缩压和舒张压均呈正相关。同样，大气 PM 浓度与血清中锰和砷的浓度呈正相关，与血清中镍、锡和铬的浓度呈负相关。只有钼的血清浓度与收缩压呈负相关。我们的结论是，大气 PM 暴露可能导致血压升高，这可能是通过干扰人体内各种金属（类）物质的内部摄入造成的。
