中心体的结构与功能。

Centrosome organization and functions.

机构信息

Institut Curie, PSL University, CNRS - UMR 144, 75005 Paris, France.

出版信息

Curr Opin Struct Biol. 2021 Feb;66:199-206. doi: 10.1016/j.sbi.2020.11.002. Epub 2020 Dec 15.

DOI:10.1016/j.sbi.2020.11.002

Abstract

The centrosome, discovered near 1875, was named by Boveri when proposing the chromosomal theory of heredity. After a long eclipse, a considerable amount of molecular data has been accumulated on the centrosome and its biogenesis in the last 30 years, summarized regularly in excellent reviews. Major questions are still at stake in 2021 however, as we lack a comprehensive view of the centrosome functions. I will first try to see how progress towards a unified view of the role of centrosomes during evolution is possible, and then review recent data on only some of the many important questions raised by this organelle.

摘要

中心体于 1875 年左右被发现，当时被命名为“Boveri”，以提出染色体遗传理论。在经历了长时间的沉寂之后，在过去的 30 年中，人们积累了大量关于中心体及其生物发生的分子数据，并定期在优秀的综述中进行总结。然而，到 2021 年，仍然存在一些重大问题，因为我们缺乏对中心体功能的全面了解。我将首先尝试探讨如何朝着对中心体在进化过程中的作用的统一观点取得进展，然后仅回顾有关这个细胞器提出的许多重要问题中的一些最新数据。