Department of Pharmacology in Dentistry, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Med Hypotheses. 2021 Jan;146:110448. doi: 10.1016/j.mehy.2020.110448. Epub 2020 Dec 9.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is able to produce an excessive host immune reaction and may leads to severe disease- a life-threatening condition occurring more often in patients suffering from comorbidities such as hypertension, diabetes and obesity. Infection by human corona viruses highly depends on host microRNA (miR) involved in regulation of host innate immune response and inflammation-modulatory miR-146a is among the first miRs induced by immune reaction to a virus. Moreover, recent analysis showed that miR-146 is predicted to target at the SARS-CoV-2 genome. As the dominant regulator of Toll-like receptors (TLRs) downstream signaling, miR-146a may limit excessive inflammatory response to virus. Downregulation of circulating miR-146a was found in diabetes, obesity and hypertension and it is reflected by enhanced inflammation and fibrosis, systemic effects accompanying severe COVID-19. Thus it could be hypothesized that miR-146a deficiency may contribute to severe COVID-19 state observed in diabetes, obesity and hypertension but further investigations are needed.
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染能够引起宿主过度的免疫反应，并可能导致严重疾病——这种危及生命的情况更常发生在患有高血压、糖尿病和肥胖等合并症的患者中。人类冠状病毒的感染高度依赖于参与宿主固有免疫反应调节的宿主 microRNA (miR)，而 miR-146a 是对病毒免疫反应最早诱导的 miR 之一。此外，最近的分析表明，miR-146 被预测靶向 SARS-CoV-2 基因组。作为 Toll 样受体 (TLRs) 下游信号的主要调节剂，miR-146a 可能限制病毒引起的过度炎症反应。在糖尿病、肥胖和高血压中发现循环 miR-146a 下调，其反映为炎症和纤维化增强，这是伴随严重 COVID-19 的全身效应。因此，可以假设 miR-146a 缺乏可能导致糖尿病、肥胖和高血压患者中观察到的严重 COVID-19 状态，但需要进一步研究。
