病毒急性呼吸道感染中的微小RNA：免疫调节、生物标志物、治疗及疫苗
microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines.
作者信息
Leon-Icaza Stephen A, Zeng Mingtao, Rosas-Taraco Adrian G
机构信息
Department of Immunology, Faculty of Medicine, Universidad Autónoma de Nuevo León, Monterrey, NL Mexico.
Center of Emphasis in Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, El Paso, TX 79905-2827 USA.
出版信息
ExRNA. 2019;1(1):1. doi: 10.1186/s41544-018-0004-7. Epub 2019 Feb 14.
MicroRNAs (miRNAs) are single-stranded RNAs of 17-24 nt. These molecules regulate gene expression at the post-transcriptional level and are differentially expressed in viral acute respiratory infections (ARIs), which are responsible for high morbidity and mortality around the world. In recent years, miRNAs have been studied in order to discover anti-viral ARI drug targets as well as biomarkers for diagnosis, severity, and prognosis. This review presents an analysis of the regulatory response to viral ARIs of miRNAs, including their participation in the innate immune response, their utility as biomarkers, and their potential for future therapies and vaccine development.
微小RNA（miRNA）是17 - 24个核苷酸的单链RNA。这些分子在转录后水平调节基因表达，并且在病毒性急性呼吸道感染（ARI）中差异表达，而病毒性急性呼吸道感染在全球范围内导致高发病率和死亡率。近年来，人们对miRNA进行了研究，以发现抗病毒ARI药物靶点以及用于诊断、病情严重程度和预后的生物标志物。本综述对miRNA对病毒性ARI的调节反应进行了分析，包括它们在先天免疫反应中的参与情况、作为生物标志物的效用以及它们在未来治疗和疫苗开发中的潜力。
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