Feghali James, Pennington Zach, Ehresman Jeff, Lubelski Daniel, Cottrill Ethan, Ahmed A Karim, Schilling Andrew, Sciubba Daniel M
J Neurosurg Spine. 2020 Dec 18;34(3):383-389. doi: 10.3171/2020.7.SPINE201136. Print 2021 Mar 1.
Symptomatic spinal metastasis occurs in around 10% of all cancer patients, 5%-10% of whom will require operative management. While postoperative survival has been extensively evaluated, postoperative health-related quality-of-life (HRQOL) outcomes have remained relatively understudied. Available tools that measure HRQOL are heterogeneous and may emphasize different aspects of HRQOL. The authors of this paper recommend the use of the EQ-5D and Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ), given their extensive validation, to capture the QOL effects of systemic disease and spine metastases. Recent studies have identified preoperative QOL, baseline functional status, and neurological function as potential predictors of postoperative QOL outcomes, but heterogeneity across studies limits the ability to derive meaningful conclusions from the data. Future development of a valid and reliable prognostic model will likely require the application of a standardized protocol in the context of a multicenter study design.
有症状的脊柱转移发生在所有癌症患者中的比例约为10%，其中5%-10%的患者需要手术治疗。虽然术后生存率已得到广泛评估，但术后健康相关生活质量（HRQOL）结果的研究相对较少。现有的测量HRQOL的工具各不相同，可能会强调HRQOL的不同方面。鉴于其广泛的验证，本文作者建议使用EQ-5D和脊柱肿瘤学研究组结局问卷（SOSGOQ）来评估全身性疾病和脊柱转移对生活质量的影响。最近的研究已确定术前生活质量、基线功能状态和神经功能是术后生活质量结果的潜在预测因素，但研究之间的异质性限制了从数据中得出有意义结论的能力。未来开发一个有效且可靠的预后模型可能需要在多中心研究设计的背景下应用标准化方案。
