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在癌症成像与治疗领域中使用聚合物体系的基于光的纳米药物。

Photo-Based Nanomedicines Using Polymeric Systems in the Field of Cancer Imaging and Therapy.

作者信息

Husni Patihul, Shin Yuseon, Kim Jae Chang, Kang Kioh, Lee Eun Seong, Youn Yu Seok, Rusdiana Taofik, Oh Kyung Taek

机构信息

Department of Global Innovative Drugs, College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Dongjak-gu, Seoul 06974, Korea.

Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si 14662, Gyeonggi-do, Korea.

出版信息

Biomedicines. 2020 Dec 16;8(12):618. doi: 10.3390/biomedicines8120618.

Abstract

The use of photo-based nanomedicine in imaging and therapy has grown rapidly. The property of light in converting its energy into different forms has been exploited in the fields of optical imaging (OI) and phototherapy (PT) for diagnostic and therapeutic applications. The development of nanotechnology offers numerous advantages to overcome the challenges of OI and PT. Accordingly, in this review, we shed light on common photosensitive agents (PSAs) used in OI and PT; these include fluorescent and bioluminescent PSAs for OI or PT agents for photodynamic therapy (PDT) and photothermal therapy (PTT). We also describe photo-based nanotechnology systems that can be used in photo-based diagnostics and therapies by using various polymeric systems.

摘要

基于光的纳米医学在成像和治疗中的应用发展迅速。光将其能量转化为不同形式的特性已在光学成像(OI)和光疗(PT)领域用于诊断和治疗应用。纳米技术的发展提供了许多优势,以克服OI和PT面临的挑战。因此,在本综述中,我们阐明了OI和PT中使用的常见光敏剂(PSA);这些包括用于OI的荧光和生物发光PSA或用于光动力疗法(PDT)和光热疗法(PTT)的PT剂。我们还描述了可以通过使用各种聚合物系统用于基于光的诊断和治疗的基于光的纳米技术系统。

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