Brocca Ginevra, Centelleghe Cinzia, Padoan Elisa, Stoppini Riccardo, Giudice Chiara, Castagnaro Massimo, Zappulli Valentina
Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, Italy.
Equine Veterinary Practitioner, Chioggia, 30015 Venice, Italy.
Animals (Basel). 2020 Dec 16;10(12):2409. doi: 10.3390/ani10122409.
A 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. Subsequently, the mare was presented with rapidly spreading multiple subcutaneous masses and, at the onset of neurological signs, was humanely euthanized and subjected to a complete post mortem examination. The necropsy confirmed the presence of numerous widespread masses in the subcutaneous tissue, several internal organs, and mammary gland. Histological and immunohistochemical (IHC) examinations were performed on all masses, allowing the diagnosis of mammary carcinoma with several visceral and subcutaneous metastases. Considering the post mortem findings, the second intraocular mass was submitted to histological and IHC re-evaluation to differentiate it from an intraocular metastasis of the mammary carcinoma. The results of the histological and IHC analyses confirmed the diagnosis of neuroepithelial tumor relapse. This is the first case of a metastatic mammary carcinoma concurrent with a recurrent intraocular neuroepithelial tumor in a mare. This case was a challenge for both clinicians and pathologists involved and highlighted the importance of post mortem and IHC evaluations.
一匹24岁的爱尔兰科布母马被发现患有周边虹膜肿物，该肿物经手术切除，诊断为未分化神经上皮肿瘤。几个月后，肿瘤复发，组织学特征表现为外观更坚实且有鳞状分化。随后，这匹母马出现多个皮下肿物迅速扩散的情况，在出现神经症状时，对其实施了安乐死并进行了全面的尸检。尸检证实皮下组织、多个内脏器官和乳腺中存在大量广泛分布的肿物。对所有肿物进行了组织学和免疫组织化学（IHC）检查，确诊为伴有多处内脏和皮下转移的乳腺癌。考虑到尸检结果，对第二个眼内肿物进行了组织学和IHC重新评估，以将其与乳腺癌的眼内转移区分开来。组织学和IHC分析结果证实为神经上皮肿瘤复发。这是首例母马发生转移性乳腺癌并伴有复发性眼内神经上皮肿瘤的病例。该病例对参与其中的临床医生和病理学家来说都是一个挑战，并凸显了尸检和IHC评估的重要性。
