Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences, "Magna Graecia" University of Catanzaro, Viale Europa, 88100, Catanzaro, Italy.
Department of Health Sciences, Unit of Clinical Microbiology, University "Magna Graecia", Catanzaro, Italy.
J Med Case Rep. 2020 Dec 18;14(1):246. doi: 10.1186/s13256-020-02595-3.
In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.
We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.
Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).
2019 年 12 月，一种新型冠状病毒（命名为严重急性呼吸综合征冠状病毒 2，SARS-CoV-2）从中国传播开来，在很短的时间内引发了一场大流行。SARS-CoV-2 感染（COVID-19，冠状病毒病 2019）的主要临床表现是肺炎，但也可能发生几种心血管并发症（例如，急性冠状动脉综合征、肺栓塞、中风、心律失常、心力衰竭和心源性休克）。SARS-CoV-2 诱导的直接或间接机制可能与这些事件的发病机制有关。
我们在此报告迄今为止第三例 COVID-19 自身免疫性溶血性贫血（AIHA）病例，在一名高加索患者中，目前尚无其他可能的解释。该患者还患有 ST 段抬高性心肌损伤。
这两种并发症均发生在 COVID-19 诊断后相当长的时间，并且可能是由全身炎症引起的，炎症标志物（包括白细胞介素 6（IL-6））的显著延迟增加表明了这一点。
