Clinical Laboratory, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Data and Project Management Unit, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
BMC Infect Dis. 2019 Jul 29;19(1):670. doi: 10.1186/s12879-019-4313-8.
Human papillomavirus (HPV) infection is the main cause of precancerous lesions and cervical cancer in women. In order to determine the epidemiological characteristics as well as the relationship between the HPV genotype and cytology test results among women in Beijing, China, we retrospectively collected and analyzed the data from a tertiary hospital in Beijing, China.
A total of 21,239 women visited the China-Japan Friendship Hospital between 2014 and 2018 and their cervical exfoliations were collected. Thirteen HPV subtypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68) were examined and ThinPrep cytological test (TCT) was performed.
Among all cases, 4473 (21.06%) women were infected with HPV. HPV52 (4.64%), HPV16 (4.44%) and HPV58 (4.28%) had higher prevalence. Single-type infection (77.26%) was more common than multiple-type infection (22.74%). Single-type infection was more frequently seen in women aged 50-60 years (17.17%), and multiple-type infection was more common in those aged < 30 years (7.88%). Significant differences in secular trends from 2014 to 2018 were observed for subtypes HPV39, 51, 52 and 58. HPV positive rates of women aged < 30 and 30-40 years changed significantly along with the time period, and the TCT positive rates of women aged 30-40, 40-50, 50-60 and > 60 years also showed significant differences from 2014 to 2018. In addition, 1746 (8.22%) women were TCT positive, of whom, 858 (4.04%), 561 (2.64%) and 327 (1.54%) had atypical squamous cells (ASCs), low-grade squamous intraepithelial lesions (LSILs) and high-grade squamous intraepithelial lesions (HSILs), respectively. Among four types of cytological lesions, the HPV infection rates were 16.76, 66.08, 63.99 and 85.32% in those negative for intraepithelial lesions or malignancy (NILM), ASC, LSIL and HSIL, respectively.
HPV52, 16 and 58 are the most common infection subtypes in this study and among four types of cytological lesions, HSILs has the highest HPV prevalence. Significant differences in secular trends are observed for different subtypes in recent 5 years. The results on HPV genotype-specific prevalence should be considered when the HPV vaccine program is implemented in Beijing area.
人乳头瘤病毒（HPV）感染是导致女性癌前病变和宫颈癌的主要原因。为了确定中国北京地区女性 HPV 感染的流行病学特征以及 HPV 基因型与细胞学检测结果之间的关系，我们回顾性收集并分析了中国北京一家三级医院的数据。
2014 年至 2018 年间，共有 21239 名女性在中国中日友好医院就诊，采集了她们的宫颈脱落细胞。检测了 13 种 HPV 亚型（16、18、31、33、35、39、45、51、52、56、58、59 和 68），并进行了 ThinPrep 细胞学检测（TCT）。
在所有病例中，4473 名（21.06%）女性感染了 HPV。HPV52（4.64%）、HPV16（4.44%）和 HPV58（4.28%）的感染率较高。单一型感染（77.26%）比多型感染（22.74%）更为常见。50-60 岁的女性中单一型感染更为常见（17.17%），而<30 岁的女性中多型感染更为常见（7.88%）。2014 年至 2018 年期间，HPV39、51、52 和 58 亚型的流行趋势存在显著差异。<30 岁和 30-40 岁女性 HPV 阳性率随时间变化显著，30-40 岁、40-50 岁、50-60 岁和>60 岁女性的 TCT 阳性率也与 2014 年至 2018 年期间存在显著差异。此外，1746 名（8.22%）女性 TCT 阳性，其中 858 名（4.04%）、561 名（2.64%）和 327 名（1.54%）分别为非典型鳞状细胞（ASC）、低度鳞状上皮内病变（LSIL）和高度鳞状上皮内病变（HSIL）。在四种细胞学病变类型中，HPV 感染率分别为 NILM、ASC、LSIL 和 HSIL 阴性者的 16.76%、66.08%、63.99%和 85.32%。
HPV52、16 和 58 是本研究中最常见的感染亚型，在四种细胞学病变类型中，HSIL 具有最高的 HPV 阳性率。在过去 5 年中，不同亚型的流行趋势存在显著差异。在北京市实施 HPV 疫苗接种计划时，应考虑 HPV 基因型的流行情况。
