雷尼替丁与雷尼替丁加普拉西泮治疗十二指肠溃疡的短期疗效比较——一项双盲对照试验
Ranitidine versus ranitidine and prazepam in the short-term treatment of duodenal ulcer--a double-blind controlled trial.
作者信息
Hüscher C, Magni G, Salmi A, Bossini S, Felini C, Besozzi F, de Leo D
出版信息
Eur J Clin Pharmacol. 1985;28(2):177-80. doi: 10.1007/BF00609688.
Fifty out-patients with an active, endoscopically proven duodenal ulcer were entered a double-blind trial of ranitidine + prazepam or ranitidine + placebo. Two drop-outs occurred in the prazepam group and 1 in the placebo group. After 28 days of treatment, the ulcer had healed in 95.6% of the patients on ranitidine + prazepam and 75% of the patients on ranitidine + placebo (p = 0.03). Sleepiness was the most frequent side effect, reported by 8 subjects in the prazepam group and by 1 subject in the placebo group. It is concluded that prazepam can be usefully combined with ranitidine in the short-term treatment of duodenal ulcer.
五十名经内镜检查确诊为活动性十二指肠溃疡的门诊患者进入了一项雷尼替丁+普拉西泮或雷尼替丁+安慰剂的双盲试验。普拉西泮组有两名患者退出，安慰剂组有一名患者退出。治疗28天后，雷尼替丁+普拉西泮组95.6%的患者溃疡愈合，雷尼替丁+安慰剂组75%的患者溃疡愈合（p = 0.03）。嗜睡是最常见的副作用，普拉西泮组有8名受试者报告，安慰剂组有1名受试者报告。得出结论，在十二指肠溃疡的短期治疗中，普拉西泮可有效地与雷尼替丁联合使用。
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