两种未被描述的二芳基庚烷类化合物，来自 的绿色外壳，作为乙酰胆碱酯酶抑制剂。
Two undescribed diarylheptanoids from green husk of as acetylcholinesterase inhibitors.
机构信息
Natural Product Chemistry & Process Development, CSIR-Institute of Himalayan Bioresource Technology, Palampur, India.
Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur, India.
出版信息
Nat Prod Res. 2022 Mar;36(5):1161-1169. doi: 10.1080/14786419.2020.1862833. Epub 2020 Dec 21.
Two undescribed diarylheptanoids, 3-()-acetyl-1-(3',4'-dihydroxyphenyl)-7-(4''-hydroxy-3'' -methoxyphenyl)-heptane () and 11-Hydroxy-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane () together with known compounds, namely, 11-Oxo-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane () 3,4,5-Trihydroxytetralone () 4,8- Dihydroxytetralone (), 4,5-Dihydroxytetralone (), 5,8-Dihydroxy-3-methoxytetralone () were isolated from ethyl acetate extract of the green husk of . The structures of compounds were established on the basis of IR, H NMR, C NMR, DEPT, HSQC, HMBC, COSY spectroscopic and ESI-MS analysis. The isolated compounds were evaluated for AChE (acetylcholinesterase inhibition) and observed that compound was potent inhibitor with IC of 101.48 ± 4.00 µg/mL.
两种未被描述的二芳基庚烷类化合物，3-()-乙酰基-1-(3',4'-二羟基苯基)-7-(4''-羟基-3'' -甲氧基苯基)-庚烷 () 和 11-羟基-1,17-环氧-7-(2-羟基苯基)-13-(16-甲氧基苯基)-庚烷 () 与已知化合物一起，即 11-氧代-1,17-环氧-7-(2-羟基苯基)-13-(16-甲氧基苯基)-庚烷 () 3,4,5-三羟基四氢酮 () 4,8-二羟基四氢酮 (), 4,5-二羟基四氢酮 (), 5,8-二羟基-3-甲氧基四氢酮 () 从 的绿壳的乙酸乙酯提取物中分离得到。化合物的结构是基于 IR、H NMR、C NMR、DEPT、HSQC、HMBC、COSY 光谱和 ESI-MS 分析确定的。对分离得到的化合物进行了 AChE（乙酰胆碱酯酶抑制）评估，结果表明化合物 是一种有效的抑制剂，IC 为 101.48 ± 4.00 µg/mL。
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