Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Nat Prod Res. 2022 Feb;36(4):1115-1117. doi: 10.1080/14786419.2020.1853726. Epub 2020 Dec 21.
The present study aims at evaluating potential of the ethanol extracts of leaves (LE), flowers (FlE) and roots (RE) in the treatment of renal calculi and characterising the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and uric acid) against ethylene glycol (EG) injuries, and restored the activity of glutathione peroxidase (GPx), superoxide dismutase and lipid peroxide malondialdehyde to the normal level. In addition, FlE significantly attenuated iNOS tissue expression caused by EG. The results obtained in this study suggest the potential value of the L. flowers as an antiurolithiatic agent.
本研究旨在评估叶（LE）、花（FlE）和根（RE）的乙醇提取物在治疗肾结石方面的潜力，并对活性提取物中的次生代谢产物进行表征。结果表明，FlE 可显著降低乙二醇（EG）损伤引起的肾脏参数（钙、肌酐、尿素和尿酸）水平，并将谷胱甘肽过氧化物酶（GPx）、超氧化物歧化酶和脂质过氧化物丙二醛的活性恢复到正常水平。此外，FlE 还显著减轻了 EG 引起的 iNOS 组织表达。本研究结果表明，L. 花具有作为抗结石剂的潜在价值。
